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Table 1 Reported cases of synchronous co-existing of PTC and LCH in the thyroid gland

From: BRAF gene mutations in synchronous papillary thyroid carcinoma and Langerhans cell histiocytosis co-existing in the thyroid gland: a case report and literature review

Author/Year Sex/Age PTC&LCH In Thyroid Side LCH in other organs Treatment BRAF mutations Follow up (months)
Goldstein N, 1991 [9] F/31 Yes Left Bone, Pituitary gland, Lung, Skin, Vagina Surgery, Prednisone, Vincristine, Methotrexate, Chlorambucil NR DF (6)
Saiz E, 2000 [10] M/43 Yes Left No Surgery NR DF(24)
Foulet-Roge A, 2002 [11] F/42 Yes Left No Surgery NR DF (14)
Burnett A, 2008 [12] M/3 LCH in Right, PTC in Left Bilateral Lung Surgery, Prednisone, Mercaptopurine, Methotrexate NR NR
Jamaati HR, 2009 [13] M/24 Yes Bilateral Lung Surgery, Etoposide, Dexamethasone NR DF(NR)
Vergez S, 2010 [1] M/29 Yes Bilateral Bone, Pituitary gland, Lung, Skin Corticosteroids, Vinblastine, Cladribine, Imatinib NR DRD(36)
Chung DH, 2012 [2] F/53 Yes Right NR Surgery NR NR
Ceyran AB, 2014 [14] M/37 Yes Bilateral NR Surgery NR Died due to Cardiac arrest
Gordon M S, 2016 [16] F/22 Yes Bilateral Labia Vulva Surgery, Prednisone V600E in PTC NR
Alzahrani R, 2016 [7] F/27 Yes Bilateral No Surgery, CT Prednisone NR NR
Wu X, 2017 [8] M/40 Yes Right Lung, Liver Surgery, CT NR DF(24)
Jaimanti Bakshi JK,2018 [15] M/31 Yes Right No Surgery, Vinblastine and Etoposide NR NR
Current case F/37 Yes Bilateral No Surgery, Prednisone with Etoposide V600E in PTC,V600K in LCH DF (12)
  1. F female, M male, CT chemotherapy, NR not recorded, DF disease free, DRD death related disease