Fig. 4

a Changes in rank gene expression after treatment with 1.0 nM GnRH, 1.0 nM GnRH + 10.0 nM Teverelix, 10.0 nM kisspeptin, 100.0 pM 17β-estradiol, 1.0 nM GnRH + 100 pM 17β-estradiol, 10.0 nM kisspeptin + 100.0 pM 17β-estradiol, or 5HT (3.0 μM and 12.0 μM). b Changes in rankl gene expression after treatment with hormones described above (*, p < 0.05; **, p < 0.01, n = 6/treatment). c Changes in opg gene expression after treatment with hormones described above