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Table 1 Correlation between clinicopathological features and ACTA2/IL6 mRNA co-expression in bladder cancer patients

From: Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

Features No. of patients ACTA2/IL6 expression p value
Low/Low High/High
Age (years)
 < 65 53 28 (52,8%) 25 (47,2%) 0.6950
 > 65 51 24 (47,1%) 27 (52,9%)
Gender
 Male 85 48 (56,5%) 37 (43,5%) 0.0058**
 Female 19 4 (21,1%) 15 (78,9%)
Invasiveness
 Superficial 67 43 (64,2%) 24 (35,8%) 0.0001****
 Invasive 37 9 (24,3%) 28 (75,7%)
Grade
 Low 75 43 (57,3%) 32 (42,7%) 0.0179*
 High 29 9 (31,0%) 20 (69,0%)
Lymph node metastasis
 N0 92 50 (54,3%) 42 (45,7%) 0.0281*
 N1, N2 11 2 (18,2%) 9 (81,8%)
Metastatic invasion
 M0 99 50 (50,5%) 49 (49,5%) 1.000
 M1 5 2 (40,0%) 3 (60,0%)
Recurrence (non-invasive cancer only)
 No 36 26 (72,2%) 10 (27,8%) 0.2016
 Yes 31 17 (54,8%) 14 (45,2%)
Progression
 No 63 34 (54,0%) 29 (46,0%) 0.3254
 Yes 41 18 (43,9%) 23 (56,1%)
  1. Fisher’s exact test with 50% lower or higher level of mRNA expression