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Table 2 Results from the multivariablea analysis using the mixture cure model on the significant SNPs identified by the univariable mixture cure model

From: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Genomic location Genetic model rs number (genotypes a vs. b) Genotype freq. Metastasis probability Time-to-metastasis
OR 95% CI p-value HR 95% CI p-value
22:17793969 Recessive rs5749032 (GG vs. AA + AG) 14% 0.38 0.14–1.07 0.066 15.86 6.83–36.83 1.28 × 10−10
17:77361176 Co-Dominant rs12949587 (CT vs. CC) 20% 0.66 0.32–1.37 0.261 7.56 3.44–16.61 4.63 × 10−7
20:15111138 Co-Dominant rs6110524 (AG vs. GG) 17% 0.95 0.44–2.04 0.887 4.80 2.00–11.53 4.52 × 10−4
7:33913404 Recessive rs3815652 (TT vs. CC + CT) 4% 0.59 0.13–2.65 0.488 12.97 3.26–51.66 2.78 × 10−4
14:100691178 Recessive rs756055 (CC vs. TT + TC) 13% 0.28 0.10–0.82 0.020 7.58 2.53–22.65 2.90 × 10−4
14:100730920 Recessive rs7153665 (AA vs. GG + AG) 13% 0.28 0.10–0.82 0.020 7.58 2.53–22.65 2.90 × 10−4
11:100430053 Recessive rs4754687 (AA vs. CC + CA) 11% 0.51 0.18–1.43 0.201 8.13 2.59–25.53 3.28 × 10−4
5:155345221 Dominant rs2163746 (CT + CC vs. TT) 24% 0.49 0.23–1.07 0.075 9.65 3.67–25.37 4.29 × 10−6
5:155361116 Dominant rs17053011 (TG + TT vs. GG) 24% 0.49 0.23–1.07 0.075 9.65 3.67–25.37 4.29 × 10−6
  1. aAdjusted for the significant baseline characteristics: tumor location, 5-fluorouracil treatment status, and tumor stage. Each SNP was analyzed separately adjusting for these factors. Patients with missing data were excluded, resulting in the inclusion of 349 stage I-III patients with MSI-L/MSS tumors
  2. Linkage disequilibrium (LD) calculations indicated that rs756055 and rs7153665 as well as rs2163746 and rs17053011 are in complete pairwise LD (r2 = 1)
  3. The SNPs listed yielded similar hazard ratio estimates under the univariable (Additional file 1: Table S3) and multivariable analyses. Consequently, all of the SNPs identified in this study could be considered independent prognostic factors for time-to-metastasis in colorectal cancer if the results are replicated using independent cohort data
  4. Genotype freq. frequency of genotype a calculated from the patient cohort, OR odds ratio for metastasis comparing odds of metastasis in subgroup a with that in subgroup b, HR hazard ratio comparing metastasis rate in subgroup a with that in subgroup b among those who are susceptible to metastasis, CI confidence interval