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Table 2 Top 20 significant GO (biological process) terms associated with transcripts that were differentially expressed between the treated and untreated groups

From: Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells

GO_ID Term Annotated Significant Expected p-value
GO:0006355 Regulation of transcription, DNA-template 2829 129 110 3.3e-26
GO:0051301 Cell division 510 96 19.83 5.0e-26
GO:0006281 DNA repair 358 47 13.92 4.6e-25
GO:0007067 Mitotic nuclear division 309 74 13.92 2.1e-23
GO:0006397 mRNA processing 317 23 12.33 4.2e-23
GO:0007049 Cell cycle 1129 167 43.9 1.2e-19
GO:0008380 RNA splicing 254 17 9.88 5.5e-19
GO:0000122 Negative regulation of transcription from RNA polymerase II promoter 539 41 20.96 6.6e-19
GO:0015031 Protein transport 1256 63 48.84 9.5e-19
GO:0006886 Intracellular protein transport 651 38 25.31 2.6e-18
GO:0006364 rRNA processing 111 3 4.32 4.2e-15
GO:0016567 Protein ubiquitination 484 28 18.82 1.7e-14
GO:0045944 Positive regulation of transcription from RNA polymerase II promoter 716 45 27.84 4.5e-14
GO:0006260 DNA replication 232 51 9.02 1.1e-13
GO:0045893 Positive regulation of transcription, DNA template 1074 62 41.76 4.7e-13
GO:0045892 Negative regulation of transcription, DNA template 860 58 33.44 1.8e-11
GO:0001701 In utero embryonic development 371 29 14.43 2.9e-11
GO:0006915 Apoptotic process 1336 91 51.95 6.5e-11
GO:0051726 Regulation of cell cycle 560 82 21.77 1.2e-10
GO:0008285 Negative regulation of cell proliferation 449 30 17.46 2.4e-10
  1. This table aims to highlight the most relevant GO terms associated with the differentially expressed transcripts in the comparison to ascertain whether certain biological functions were enriched among the transcripts compared with the reference background. This analysis is a type of gene enrichment test and does not ensure that the transcripts that belong to a significant GO term are up or downregulated. It does ensure, however, that a group of differentially expressed genes with similar functionality are significantly over-represented. The expected values represent an estimate of the number of transcripts associated with the given significant GO term at random among all the annotated differentially expressed genes. The significant (observed) values represent the number of differentially expressed transcripts associated with that particular GO term in the sample (real) dataset. Annotations represent the total number of genes associated with that GO term in the sample dataset, which means that the reference background could potentially have a larger number of annotations. The q value represents the test statistics for the given GO term whether or not it is significantly enriched
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BMC Cancer

ISSN: 1471-2407

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