Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells

Table 2 Top 20 significant GO (biological process) terms associated with transcripts that were differentially expressed between the treated and untreated groups

GO_ID	Term	Annotated	Significant	Expected	p-value
GO:0006355	Regulation of transcription, DNA-template	2829	129	110	3.3e-26
GO:0051301	Cell division	510	96	19.83	5.0e-26
GO:0006281	DNA repair	358	47	13.92	4.6e-25
GO:0007067	Mitotic nuclear division	309	74	13.92	2.1e-23
GO:0006397	mRNA processing	317	23	12.33	4.2e-23
GO:0007049	Cell cycle	1129	167	43.9	1.2e-19
GO:0008380	RNA splicing	254	17	9.88	5.5e-19
GO:0000122	Negative regulation of transcription from RNA polymerase II promoter	539	41	20.96	6.6e-19
GO:0015031	Protein transport	1256	63	48.84	9.5e-19
GO:0006886	Intracellular protein transport	651	38	25.31	2.6e-18
GO:0006364	rRNA processing	111	3	4.32	4.2e-15
GO:0016567	Protein ubiquitination	484	28	18.82	1.7e-14
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	716	45	27.84	4.5e-14
GO:0006260	DNA replication	232	51	9.02	1.1e-13
GO:0045893	Positive regulation of transcription, DNA template	1074	62	41.76	4.7e-13
GO:0045892	Negative regulation of transcription, DNA template	860	58	33.44	1.8e-11
GO:0001701	In utero embryonic development	371	29	14.43	2.9e-11
GO:0006915	Apoptotic process	1336	91	51.95	6.5e-11
GO:0051726	Regulation of cell cycle	560	82	21.77	1.2e-10
GO:0008285	Negative regulation of cell proliferation	449	30	17.46	2.4e-10

This table aims to highlight the most relevant GO terms associated with the differentially expressed transcripts in the comparison to ascertain whether certain biological functions were enriched among the transcripts compared with the reference background. This analysis is a type of gene enrichment test and does not ensure that the transcripts that belong to a significant GO term are up or downregulated. It does ensure, however, that a group of differentially expressed genes with similar functionality are significantly over-represented. The expected values represent an estimate of the number of transcripts associated with the given significant GO term at random among all the annotated differentially expressed genes. The significant (observed) values represent the number of differentially expressed transcripts associated with that particular GO term in the sample (real) dataset. Annotations represent the total number of genes associated with that GO term in the sample dataset, which means that the reference background could potentially have a larger number of annotations. The q value represents the test statistics for the given GO term whether or not it is significantly enriched

ISSN: 1471-2407