Fig. 5

Patient survival with respect to the expression signature of CD133 and stromal cells. a A heatmap shows the relationship of the signature levels including CIS signature (indicated by an arrow) in TCGA GC expression profiles. Yellow and red represent high and low signature levels, respectively. The number of genes in the signatures are shown in parenthesis. b Kaplan–Meier survival curves are shown for TCGA GC patients with high and low CD133 expression signature levels (red and blue, respectively; left). Significance was estimated using the log-rank test and shown in the panel. Similarly analyzed for the level of stromal signatures (right) (c) For 21 tumor types including GC (STAD), hazard ratios for CIS and stromal signature levels (green and red lines, respectively) estimated by multivariate Cox regression are shown. Significance levels are indicated by asterisks with individual plots