Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis

BMC Cancer

Table 2 Subgroup analysis for association between Ki-67 expression and overall survival

Term	Subgroup	Number	Pooled	95%CI	P	Heterogeneity	P
Term		of study	HR			I ²
Location	Asian	10	1.89	1.23–2.90	0.003	70.9	0.001
Location	Non- Asian	11	1.282	0.936–1.758	0.122	77.4	0.001
Cut off value	≥40%	9	1.5	1.01–2.24	0.044	84.9	0.001
Cut off value	<40%	10	1.71	1.33–2.21	0.001	0	0.529
Patient number	≥100	13	1.381	0.994–1.918	0.054	75.7	0.001
Patient number	<100	8	2.008	1.131–3.564	0.017	79.4	0.001
Positive rate^a	≥50%	14	1.513	1.119–2.046	0.007	64.2	0.001
Positive rate^a	<50%	6	1.589	0.911–2.773	0.103	86.5	0.001
Pathologic type	CRC	14	1.526	1.135–2.05	0.005	62.8	0.001
	CC	2	2.257	1.418–3.594	0.001	77.7	0.001
	RC	2	0.743	0.332–1.662	0.469	20.7	0.261
	CRCLM	3	1.902	0.696–5.198	0.21	92.6	0.001
Treatment	S	12	1.518	1.038–2.221	0.031	74.6	0.001
	S + C	7	1.477	0.933–2.338	0.096	82.3	0.001
	S + C + R	2	2.216	1.227–4.002	0.008	0	0.945
Extraction method	Curve	7	1.261	0.915–1.736	0.001	57.3	0.029
Extraction method	Reported	14	2.095	1.491–2.02	0.156	72.5	0.001

HR hazard ratio, CI confidence interval, CRC colorectal cancer, CRCLM colorectal liver metastases, CC colon cancer, RC rectal cancer, S surgery, C chemotherapy, R radiotherapy
^apositive status was defined according to cut off value

ISSN: 1471-2407