Table 1 Characteristics of studies included in the present meta analysis
Author/Country/Year | Detection | Quantitative | Antibody | Fixed | Positivea | Median age | History | Â | Cut off | Patient |
|---|---|---|---|---|---|---|---|---|---|---|
method | method | type | method | Rate(%) | (Range) | Type/ Stage | Therapy | Value | Number | |
Meyer [5] Germany 2009 | microscope | semi-quantitative | mouse monoclonal | formalin | 88.8% | 64(28–91) | CC II-IV | S + C | NR | 392 |
Garrity [6] Canada 2004 | NR | quantitative | NR | formalin | 62.4% | NR | CRC II-III | S + C | 27.0% | 366 |
Fodor [7] America 2012 | Tissue microarrays | quantitative | NR | formalin | 52.0% | 71.5(18–97) | CRC I-IV | S + C | 60.0% | 867 |
Salminen [8] Finland 2005 | microscope | quantitative | mouse monoclonal | formalin | 45.2% | 66(36–86) | RC I-IV | S + R | 40.0% | 146 |
Zhang [9] China 2015 | Tissue microarrays | quantitative | NR | formalin | 47.9% | 72(37–93) | CRC I-IV | S + R | 40.0% | 73 |
Yoshimura [10] Japan 2003 | microscope | quantitative | monoclonal | NR | NR | 65 | CRC III | S | 62.0% | 56 |
Li [11] China 2010 | Tissue microarrays | semi-quantitative | monoclonal | formalin | 78.8% | 65(22–95) | CC I-IV | S | 10.0% | 203 |
Li [12] China 2011 | Tissue microarrays | semi-quantitative | monoclonal | formalin | 78.8% | 65(22–95) | CC I-IV | S | 10.0% | 203 |
Dawson [13] Switzerland 2014 | Tissue microarrays | quantitative | monoclonal | formalin | NR | 71(35–93) | CRC I-IV | S + C | 30.0% | 188 |
Weber 2001 [14] France 2001 | microscope | quantitative | mouse monoclonal | formalin | 50.2% | 61(29–80) | CRCLM I-IV | S + C | 50.0% | 221 |
Xi [15] China 2011 | microscope | semi-quantitative | mouse monoclonal | formalin | 59.7% | 62(20–81) | CRC I-IV | S | score > 5 | 201 |
Ivanecz [16] Slovenia 2014 | microscope | semi-quantitative | mouse monoclonal | formalin | 28.0% | 62(27–78) | CRCLM I-IV | S + C | 50.0% | 98 |
Rosati [17] Italy 2004 | microscope | semi-quantitative | monoclonal | formalin | 55.3% | 66(29–79) | CRC II-III | S + C | 10.0% | 103 |
Nishihara [18] Japan 2009 | microscope | quantitative | mouse monoclonal | formalin | 51.2% | 68(33–94) | CRC I-IV | S | 40.0% | 201 |
Scopa [19] Greece 2003 | microscope | semi-quantitative | mouse monoclonal | NR | 64.0% | 66(25–82) | CRC I-IV | S + C | 5.0% | 117 |
Visca [20] Italy 1999 | microscope | semi-quantitative | mouse monoclonal | formalin | 90% | 64 | CRC I-IV | S | 20.0% | 100 |
Handa [21] Japan 1999 | microscope | quantitative | monoclonal | formalin | 65.8% | 66(39–90) | CRC I-IV | S | 19.5% | 73 |
Bahnassy [22] Egypt 2004 | microscope | quantitative | NR | NR | NR | NR | CRC I-IV | S | 11.5% | 60 |
Buglioni 1999 [23] | microscope | quantitative | NR | NR | 50.3% | 64(56–70) | CRC I-IV | S | 25.0% | 171 |
Bertolini [24] Italy 2007 | microscope | quantitative | NR | formalin | 90.0% | 64(26–78) | RC I-III | S + C + R | 20.0% | 91 |
Kimura [25] Japan 2000 | microscope | quantitative | monoclonal | formalin | 31.0% | 63.1 ± 10.7 | CRC II-IV | S | 50.6% | 71 |
Fernandez-Cebrian [26] Spain 2007 | microscope | semi-quantitative | mouse monoclonal | NR | 69.1% | 63.9(45–96) | CC II | S | 25.0% | 162 |
Wu 2012 [27] China 2012 | microscope | semi-quantitative | mouse monoclonal | formalin | 78.7% | 62(22–83) | CRC I-IV | S | score > 5 | 192 |
Furudoi 2001 [28] Japan 2001 | microscope | quantitative | monoclonal | formalin | 45.0% | 63.2 ± 13.9 | CRC II-IV | S + C | 47.9% | 111 |
Lin [29] China 2008 | microscope | semi-quantitative | mouse monoclonal | NR | 18.3% | 64 | CRC I-IV | S | 50.0% | 60 |
Hayashi 2015 [30] Japan 2015 | microscope | quantitative | mouse monoclonal | formalin | 63.5% | 65(35–83) | CRCLM I-IV | S + C | 30.0% | 54 |
Ajani [31] America 2010 | microscope | quantitative | monoclonal | formalin | 50.0% | NR | RC I-IV | C + R | median | 30 |
Li [32] China 2009 | microscope | quantitative | monoclonal | formalin | 78.8% | 65(22–95) | CC I-IV | S | 10.0% | 203 |
Hu 2009 [33] China 2009 | microscope | quantitative | NR | formalin | 30.7% | 56.6(34–75) | CRC NR | S | 10.0% | 52 |
Roxburgh [34] Scotland 2013 | Tissue microarrays | quantitative | mouse monoclonal | NR | 61% | NR | CRC I-III | S + C | 15% | 230 |
Shin 2014 [35] Korea 2014 | microscope | quantitative | NR | NR | 74.4% | 63(30–87) | CRC I-IV | S + C | 50.0% | 266 |
Nash [36] America 2010 | microscope | quantitative | NR | formalin | 66.0% | 63(19–84) | CRCLM I-IV | S + C | 50.0% | 188 |
Prall [37] Germany 2004 | Tissue microarrays | quantitative | mouse monoclonal | NR | 50.0% | 64.8(29–90) | CRC I-IV | S + C + R | median | 149 |
Zlobec [38] Switzerland 2008 | Tissue microarrays | quantitative | NR | NR | 42.5% | 68.7(36–96) | RC I-IV | S + C + R | 15.0% | 482 |