Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice

Lim, Young-Cheol; Kim, Hyeongi; Lim, Sang Moo; Kim, Jin Su

doi:10.1186/s12885-019-5323-z

Table 4 The alterated genes after CTX and M30 treatment

From: Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice

Angiogenesis			Aging			Cell proliferation			Cell migration
Gene symbol	Fold change		Gene symbol	Fold change		Gene symbol	Fold change		Gene symbol	Fold change
Condition 1*	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX
Shh	11.540	0.384	Gjb6	9.359	0.258	Shh	11.540	0.384	S100a8	11.647	0.555
Lef1	9.036	0.201	Krt25	5.496	0.139	Oca2	11.515	0.072	Shh	11.540	0.384
Adm2	7.801	0.213	Alox12	4.174	0.352	Lef1	10.260	0.184	Saa3	11.365	0.268
Robo1	4.914	0.418	Slc34a2	3.581	0.656	Tspan1	10.093	0.210	Foxe1	11.226	0.221
E2f8	4.537	0.307	H2afx	3.312	0.422	Lef1	9.036	0.201	Lef1	10.260	0.184
Condition 2*	CTX/Normal	MC/CTX	Condition 2	CTX/Normal	MC/CTX	Condition 2	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX
Tbx4	0.167	4.913	Ifi27l2a	0.165	1.675	Dmbt1	0.122	3.491	Ccl6	0.079	3.826
Spi1	0.163	3.851	Ccl2	0.137	2.583	Slc11a1	0.107	5.273	Ccl7	0.073	4.394
Nov	0.162	4.204	Il6	0.086	4.170	Enpep	0.103	8.165	Retnlg	0.047	21.223
Ccl2	0.137	2.583	Pot1b	0.067	2.010	Gapt	0.086	5.105	Ccl24	0.043	8.652
Enpep	0.103	8.165	Fos	0.052	4.141	Il6	0.086	4.170	Cxcl1	0.035	4.222
Cell death			Apoptosis			Inflammatory response			RNA splicing
Gene symbol	Fold change		Gene symbol	Fold change		Gene symbol	Fold change		Gene symbol	Fold change
Condition 1	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX
S100a8	11.647	0.555	S100a8	11.647	0.555	S100a8	11.647	0.555	Snrpc	4.166	0.564
Shh	11.540	0.384	Shh	11.540	0.384	Saa3	11.365	0.268	Rbfox3	3.293	0.317
Avp	10.850	0.317	Avp	10.850	0.317	Camp	4.323	2.691	Ppil1	2.778	0.480
Lef1	10.260	0.184	Lef1	10.260	0.184	Olr1	3.809	0.515	Ddx39	2.238	0.551
Gjb6	9.359	0.258	Gjb6	9.359	0.258	Crhbp	3.421	0.434	Rbmx	2.146	0.511
Condition 2	CTX/Normal	MC/CTX	Condition 2	CTX/Normal	MC/CTX	Condition 2	CTX/Normal	MC/CTX	Condition 2	CTX/Normal	MC/CTX
Ptgis	0.141	5.335	Ptgis	0.141	5.335	Pf4	0.084	5.956	Snrpn	0.527	1.992
Gzma	0.139	8.220	Gzma	0.139	8.220	Ccr5	0.083	5.403	Rbpms	0.503	1.687
Scn2a1	0.116	5.697	Scn2a1	0.116	5.697	Ccl7	0.073	4.394	Celf2	0.493	1.719
Il6	0.086	4.170	Il6	0.086	4.170	Ccl24	0.043	8.652	Rbfox1	0.211	3.440
Cd5l	0.059	3.309	Cd5l	0.059	3.309	Cxcl1	0.035	4.222	Nova1	0.171	3.988
Extracellular matrix			Immune response			Secretion
Gene symbol	Fold change		Gene symbol	Fold change		Gene symbol	Fold change
Condition 1	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX	Condition 1	CTX/Normal	MC/CTX
Col10a1	27.343	0.043	S100a8	11.647	0.555	Crhr1	15.534	0.178
Shh	11.540	0.384	Lef1	10.260	0.184	Trim9	11.777	0.246
Nav2	7.185	0.283	Exo1	5.591	0.251	Crhr1	8.741	0.170
Gpc5	3.730	0.549	Srms	4.538	0.452	Nkd2	5.288	0.463
Wnt5a	3.689	0.531	Itgal	4.378	0.482	Syt7	5.101	0.270
Condition 2	CTX/Normal	MC/CTX	Condition 2	CTX/Normal	MC/CTX	Condition 2	CTX/Normal	MC/CTX
Dmbt1	0.122	3.491	C1qa	0.057	8.083	Kcnma1	0.151	3.865
Cfp	0.118	2.918	Oas3	0.051	3.151	Fcer1g	0.118	3.346
Myoc	0.081	9.790	Ccl24	0.043	8.652	Fcgr3	0.105	6.135
Mamdc2	0.076	9.511	Fcna	0.041	12.585	Agtr2	0.092	3.212
Mmp11	0.070	8.145	Cxcl1	0.035	4.222	Il6	0.086	4.170

*Condition 1 & 2 (p < 0.05)

Back to article page

ISSN: 1471-2407

Contact us

Submission enquiries: bmccancer@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Cancer

Contact us