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Table 4 The alterated genes after CTX and M30 treatment

From: Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice

Angiogenesis Aging Cell proliferation Cell migration
Gene symbol Fold change Gene symbol Fold change Gene symbol Fold change Gene symbol Fold change
Condition 1* CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX
 Shh 11.540 0.384 Gjb6 9.359 0.258 Shh 11.540 0.384 S100a8 11.647 0.555
 Lef1 9.036 0.201 Krt25 5.496 0.139 Oca2 11.515 0.072 Shh 11.540 0.384
 Adm2 7.801 0.213 Alox12 4.174 0.352 Lef1 10.260 0.184 Saa3 11.365 0.268
 Robo1 4.914 0.418 Slc34a2 3.581 0.656 Tspan1 10.093 0.210 Foxe1 11.226 0.221
 E2f8 4.537 0.307 H2afx 3.312 0.422 Lef1 9.036 0.201 Lef1 10.260 0.184
Condition 2* CTX/Normal MC/CTX Condition 2 CTX/Normal MC/CTX Condition 2 CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX
 Tbx4 0.167 4.913 Ifi27l2a 0.165 1.675 Dmbt1 0.122 3.491 Ccl6 0.079 3.826
 Spi1 0.163 3.851 Ccl2 0.137 2.583 Slc11a1 0.107 5.273 Ccl7 0.073 4.394
 Nov 0.162 4.204 Il6 0.086 4.170 Enpep 0.103 8.165 Retnlg 0.047 21.223
 Ccl2 0.137 2.583 Pot1b 0.067 2.010 Gapt 0.086 5.105 Ccl24 0.043 8.652
 Enpep 0.103 8.165 Fos 0.052 4.141 Il6 0.086 4.170 Cxcl1 0.035 4.222
Cell death Apoptosis Inflammatory response RNA splicing
Gene symbol Fold change Gene symbol Fold change Gene symbol Fold change Gene symbol Fold change
Condition 1 CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX
 S100a8 11.647 0.555 S100a8 11.647 0.555 S100a8 11.647 0.555 Snrpc 4.166 0.564
 Shh 11.540 0.384 Shh 11.540 0.384 Saa3 11.365 0.268 Rbfox3 3.293 0.317
 Avp 10.850 0.317 Avp 10.850 0.317 Camp 4.323 2.691 Ppil1 2.778 0.480
 Lef1 10.260 0.184 Lef1 10.260 0.184 Olr1 3.809 0.515 Ddx39 2.238 0.551
 Gjb6 9.359 0.258 Gjb6 9.359 0.258 Crhbp 3.421 0.434 Rbmx 2.146 0.511
Condition 2 CTX/Normal MC/CTX Condition 2 CTX/Normal MC/CTX Condition 2 CTX/Normal MC/CTX Condition 2 CTX/Normal MC/CTX
 Ptgis 0.141 5.335 Ptgis 0.141 5.335 Pf4 0.084 5.956 Snrpn 0.527 1.992
 Gzma 0.139 8.220 Gzma 0.139 8.220 Ccr5 0.083 5.403 Rbpms 0.503 1.687
 Scn2a1 0.116 5.697 Scn2a1 0.116 5.697 Ccl7 0.073 4.394 Celf2 0.493 1.719
 Il6 0.086 4.170 Il6 0.086 4.170 Ccl24 0.043 8.652 Rbfox1 0.211 3.440
 Cd5l 0.059 3.309 Cd5l 0.059 3.309 Cxcl1 0.035 4.222 Nova1 0.171 3.988
Extracellular matrix Immune response Secretion  
Gene symbol Fold change   Gene symbol Fold change Gene symbol Fold change    
Condition 1 CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX Condition 1 CTX/Normal MC/CTX    
 Col10a1 27.343 0.043 S100a8 11.647 0.555 Crhr1 15.534 0.178    
 Shh 11.540 0.384 Lef1 10.260 0.184 Trim9 11.777 0.246    
 Nav2 7.185 0.283 Exo1 5.591 0.251 Crhr1 8.741 0.170    
 Gpc5 3.730 0.549 Srms 4.538 0.452 Nkd2 5.288 0.463    
 Wnt5a 3.689 0.531 Itgal 4.378 0.482 Syt7 5.101 0.270    
Condition 2 CTX/Normal MC/CTX Condition 2 CTX/Normal MC/CTX Condition 2 CTX/Normal MC/CTX    
 Dmbt1 0.122 3.491 C1qa 0.057 8.083 Kcnma1 0.151 3.865    
 Cfp 0.118 2.918 Oas3 0.051 3.151 Fcer1g 0.118 3.346    
 Myoc 0.081 9.790 Ccl24 0.043 8.652 Fcgr3 0.105 6.135    
 Mamdc2 0.076 9.511 Fcna 0.041 12.585 Agtr2 0.092 3.212    
 Mmp11 0.070 8.145 Cxcl1 0.035 4.222 Il6 0.086 4.170    
  1. *Condition 1 & 2 (p < 0.05)