Fig. 3

Variants classified according to filters. The percent of variants classified by each of the following filters: ExAC – variants with similar or higher frequencies in ExAC; Recurrent – variants detected in ≥3 samples in COSMIC; Intronic – variants found in introns excluding splice junctions; Inactivating variant in TSG – likely inactivating factors that occur in tumor suppressor gene; GENIE recurrent – variants detected in ≥3 samples in GENIE and < 3 samples in in COSMIC; Potential artifacts – variants occurring only from a single sequencing center; and VUS – all remaining variants are considered variants of unknown significance. Newly retrieved recurrent variants revealed in this study accounts for 3% (GENIE recurrent)