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Table 7 Association between side effects and COMT rs4680 polymorphism in the studies included in the systematic review

From: Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review

Study name [ref] Variable Genotype frequency (N, %) Results (type of measure) p-value
EPOS study [20] (Barratt, 2015) Tiredness, Depression, Cognitive Dysfunction, Constipation G/G (109, 23.59)
A/G (243, 52.60)
A/A (110, 23.80)
Not reported  
[21] (Laugsand, 2011) Nausea and Vomiting EORTC Score G/G (341, 21.93)
A/G (787, 50.61)
A/A (427, 27.46)
25.8 ± 30.5
21.5 ± 26.6
26.2 ± 29.2
(mean ± SD)
0.002
[23] Rakvåg, 2005 Fatigue EORTC Score G/G (44, 21.25)
A/G (96, 46.38)
A/A (67, 32.37)
73 ± 23
62 ± 24
66 ± 22
(mean ± SD)
> 0.05
  Nausea and vomiting EORTC Score   30 ± 27
24 ± 26
29 ± 27
(mean ± SD)
> 0.05
  Dyspnea EORTC Score   39 ± 35
38 ± 34
32 ± 33
(mean ± SD)
> 0.05
  Sleep EORTC Score   39 ± 35
38 ± 34
32 ± 33
(mean ± SD)
> 0.05
  Appetite EORTC Score   64 ± 36
49 ± 38
53 ± 38
(mean ± SD)
> 0.05
  Constipation EORTC Score   56 ± 41
57 ± 37
54 ± 37
(mean ± SD)
> 0.05
[28] Ross, 2008 Central side effect G/G (46, 20.81)
A/G (119, 53.85)
A/A (56, 25.34)
Not reported 0.956
  1. EORTC European Organization for Research and Treatment of Cancer Core
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