Table 7 Association between side effects and COMT rs4680 polymorphism in the studies included in the systematic review

EPOS study [20] (Barratt, 2015)

Tiredness, Depression, Cognitive Dysfunction, Constipation

G/G (109, 23.59)

A/G (243, 52.60)

A/A (110, 23.80)

Not reported

[21] (Laugsand, 2011)

Nausea and Vomiting EORTC Score

G/G (341, 21.93)

A/G (787, 50.61)

A/A (427, 27.46)

25.8 ± 30.5

21.5 ± 26.6

26.2 ± 29.2

(mean ± SD)

[23] Rakvåg, 2005

Fatigue EORTC Score

G/G (44, 21.25)

A/G (96, 46.38)

A/A (67, 32.37)

73 ± 23

62 ± 24

66 ± 22

(mean ± SD)

Nausea and vomiting EORTC Score

30 ± 27

24 ± 26

29 ± 27

(mean ± SD)

Dyspnea EORTC Score

39 ± 35

38 ± 34

32 ± 33

(mean ± SD)

Sleep EORTC Score

39 ± 35

38 ± 34

32 ± 33

(mean ± SD)

Appetite EORTC Score

64 ± 36

49 ± 38

53 ± 38

(mean ± SD)

Constipation EORTC Score

56 ± 41

57 ± 37

54 ± 37

(mean ± SD)

[28] Ross, 2008

Central side effect

G/G (46, 20.81)

A/G (119, 53.85)

A/A (56, 25.34)

Not reported