Skip to main content

Table 2 Chemotherapy-induced peripheral neuropathy prevalence by different measures over time (N = 343)

From: Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy

Measures

Baseline

Cycle1

Cycle2

Cycle3

Cycle4

Cycle5

Cycle6

6mFU

9mFU

12mFU

n/N

%

n/N

%

n/N

%

n/N

%

n/N

%

n/N

%

n/N

%

n/N

%

n/N

%

n/N

%

NCI motor1

 Grade 1

338/341

99.1

294/308

95.5

273/290

94.1

244/273

89.4

209/242

86.4

121/142

85.2

99/120

82.5

219/255

85.9

204/234

87.2

177/194

91.2

 Grade > =2

3/341

0.9

14/308

4.5

17/290

5.9

29/273

10.6

33/242

13.6

21/142

14.8

21/120

17.5

36/255

14.1

30/234

12.8

17/194

8.8

 Grade 2

3/341

0.9

14/308

4.5

16/290

5.5

25/273

9.2

28/242

11.6

17/142

12.0

18/120

15.0

26/255

10.2

25/234

10.7

14/194

7.2

 Grade 3

    

1/290

0.4

4/273

1.5

5/242

2.1

4/142

2.8

3/120

2.5

10/255

3.9

5/234

2.1

3/194

1.6

NCI sensory1

 Grade 1

340/341

99.7

297/308

96.4

273/290

94.1

254/273

93.0

222/242

91.7

126/142

88.7

103/120

85.8

222/255

87.1

205/233

88.0

178/194

91.8

 Grade > =2

1/341

0.3

11/308

3.6

17/290

5.9

19/273

7.0

20/242

8.3

16/142

11.3

17/120

14.2

33/255

12.9

28/233

12.0

16/194

8.2

 Grade 2

1/341

0.3

11/308

3.6

16/290

5.5

13/273

4.8

17/242

7.0

14/142

9.9

16/120

13.3

28/255

11.0

26/233

11.2

14/194

7.2

 Grade 3

    

1/290

0.4

6/273

2.2

3/242

1.2

2/142

1.4

1/120

0.8

5/255

2.0

2/233

0.8

2/194

1.0

WHO CIPN 2

 Grade 0

333/341

97.7

277/308

89.9

248/290

85.5

217/273

79.5

182/242

75.2

99/142

69.7

97/120

80.8

210/255

82.4

197/234

84.2

180/194

92.8

 Grade > = 1

8/341

2.3

31/308

10.1

42/290

14.5

56/273

20.5

60/242

24.8

43/142

30.3

23/120

19.2

45/255

17.6

37/234

15.8

14/194

7.2

 Grade 1

8/341

2.3

25/308

8.1

37/290

12.8

49/273

17.9

53/242

21.9

39/142

27.5

21/120

17.5

40/255

15.7

33/234

14.1

12/194

6.2

 Grade 2

  

5/308

1.6

3/290

1.0

6/273

2.2

7/242

2.9

3/142

2.1

2/120

1.6

5/255

2.0

4/234

1.7

2/194

1.0

 Grade 3

  

1/308

0.3

2/290

0.7

1/273

0.4

  

1/142

0.7

        

Cotton wool

 Normal (−)

306/307

99.7

268/279

96.1

257/267

96.3

237/257

92.2

203/212

95.8

124/135

91.9

100/107

93.5

188/217

86.6

163/183

89.1

138/143

96.5

 Abnormal (+)

1/307

0.3

11/279

3.9

10/267

3.7

20/257

7.8

9/212

4.2

11/135

8.1

7/107

6.5

29/217

13.4

20/183

10.9

5/143

3.5

 A lot of sensation

  

4/279

1.4

8/267

3.0

2/257

0.8

    

3/107

2.8

3/217

1.4

6/183

3.3

1/143

0.7

 A bit sensation

1/307

0.3

1/279

0.4

1/267

0.4

2/257

0.8

2/212

0.9

1/135

0.7

  

21/217

9.7

12/183

6.6

4/143

2.8

 No sensation

  

6/279

2.2

1/267

0.4

16/257

6.2

7/212

3.3

10/135

7.4

4/107

3.7

5/217

2.3

2/183

1.1

  

Monofilament

 Normal (−)

306/307

99.7

290/302

96.0

272/290

93.8

246/273

90.1

198/220

90.0

121/142

85.2

92/106

86.8

187/232

80.6

162/196

82.7

137/147

93.2

 Abnormal (+)

1/307

0.3

12/302

4.0

18/290

6.2

27/273

9.9

22/220

10.0

21/142

14.8

14/106

13.2

45/232

19.4

34/196

17.3

10/147

6.9

 A lot of sensation

  

2/302

0.7

3/290

1.0

4/273

1.5

2/220

0.9

4/142

2.8

  

5/232

2.2

9/196

4.6

2/147

1.4

 A bit sensation

1/307

0.3

5/302

1.7

8/290

2.8

11/273

4.0

14/220

6.4

9/142

6.3

9/106

8.5

33/232

14.2

21/196

10.7

7/147

4.8

 No sensation

  

5/302

1.7

7/290

2.4

12/273

4.4

6/220

2.7

8/142

5.6

5/106

4.7

7/232

3.0

4/196

2.1

1/147

0.7

ECIPN-20 3

 Numbness in hands/fingers

 Grade 1

286/342

83.6

232/306

75.8

198/287

69.0

176/271

64.9

144/240

60.0

82/138

59.4

55/118

46.6

142/255

55.7

146/234

62.4

134/195

68.8

 Grade > =2

56/342

16.4

74/306

24.2

89/287

31.0

95/271

35.1

96/240

40.0

56/138

40.6

63/118

53.4

113/255

44.3

88/234

37.6

61/195

31.2

 Grade 2

50/342

14.6

55/306

18.0

62/287

21.6

72/271

26.6

66/240

27.5

36/138

26.1

36/118

30.5

73/255

28.6

67/234

28.6

49/195

25.1

 Grade 3

5/342

1.5

12/306

3.9

21/287

7.3

16/271

5.9

21/240

8.8

14/138

10.1

19/118

16.1

27/255

10.6

16/234

6.8

9/195

4.6

 Grade 4

1/342

0.3

7/306

2.3

6/287

2.1

7/271

2.6

9/240

3.8

6/138

4.3

8/118

6.8

13/255

5.1

5/234

2.1

3/195

1.5

Numbness in feet/toes

 Grade 1

308/343

89.8

244/307

79.5

217/287

75.6

188/271

69.4

146/240

60.8

81/138

58.7

65/118

55.1

142/255

55.7

148/235

63.0

138/195

70.8

 Grade > =2

35/343

10.2

63/307

20.5

70/287

24.4

83/271

30.6

94/240

39.2

57/138

41.3

53/118

44.9

113/255

44.3

87/235

37.0

57/195

29.2

 Grade 2

31/343

9.0

49/307

16.0

47/287

16.4

62/271

22.9

65/240

27.1

37/138

26.8

36/118

30.5

73/255

28.6

63/235

26.8

41/195

21.0

 Grade 3

2/343

0.6

10/307

3.3

16/287

5.6

12/271

4.4

22/240

9.2

13/138

9.4

12/118

10.2

29/255

11.4

16/235

6.8

11/195

5.6

 Grade 4

2/343

0.6

4/307

1.3

7/287

2.4

9/271

3.3

7/240

2.9

7/138

5.1

5/118

4.2

11/255

4.3

8/235

3.4

5/195

2.6

FACTGOG-Ntx 4

Numbness/tingling in hands

 Grade 0

296/343

86.3

235/307

76.5

194/287

67.6

178/271

65.7

144/240

60.0

75/138

54.3

60/119

50.4

139/255

54.5

148/235

63.0

137/195

70.3

 Grade > =1

47/343

13.7

72/307

23.5

93/287

32.4

93/271

34.3

96/240

40.0

63/138

45.7

59/119

49.6

116/255

45.5

87/235

37.0

58/195

29.7

 Grade 1

39/343

11.4

42/307

13.7

57/287

19.9

61/271

22.5

61/240

25.4

36/138

26.1

33/119

27.7

65/255

25.5

61/235

26.0

37/195

19.0

 Grade 2

4/343

1.2

17/307

5.5

12/287

4.2

10/271

3.7

15/240

6.3

8/138

5.8

14/119

11.8

18/255

7.1

9/235

3.8

8/195

4.1

 Grade 3

2/343

0.6

9/307

2.9

12/287

4.2

11/271

4.1

14/240

5.8

12/138

8.7

7/119

5.9

20/255

7.8

11/235

4.7

9/195

4.6

 Grade 4

2/343

0.6

4/307

1.3

12/287

4.2

11/271

4.1

6/240

2.5

7/138

5.1

5/119

4.2

13/255

5.1

6/235

2.6

4/195

2.1

Numbness/tingling in feet

 Grade 0

317/343

92.4

247/307

80.5

215/287

74.9

183/271

67.5

146/240

60.8

79/138

57.2

70/118

59.3

137/255

53.7

150/235

63.8

143/195

73.3

 Grade > =1

26/343

7.6

60/307

19.5

72/287

25.1

88/271

32.5

94/240

39.2

59/138

42.8

48/118

40.7

118/255

46.3

85/235

36.2

52/195

26.7

 Grade 1

17/343

5.0

35/307

11.4

44/287

15.3

58/271

21.4

65/240

27.1

35/138

25.4

30/118

25.4

69/255

27.1

54/235

23.0

34/195

17.4

 Grade 2

6/343

1.7

12/307

3.9

10/287

3.5

9/271

3.3

13/240

5.4

5/138

3.6

9/118

7.6

22/255

8.6

13/235

5.5

7/195

3.6

 Grade 3

2/343

0.6

7/307

2.3

10/287

3.5

11/271

4.1

10/240

4.2

13/138

9.4

6/118

5.1

17/255

6.7

9/235

3.8

9/195

4.6

 Grade 4

1/343

0.3

6/307

2.0

8/287

2.8

10/271

3.7

6/240

2.5

6/138

4.3

3/118

2.5

10/255

3.9

9/235

3.8

2/195

1.0

  1. 1NCI sensory/motor grading (Grade 1 = Asymptomatic not interfering with functioning, Grade 2 = Moderate symptoms limiting instrumental ADL, Grade 3 = Severe symptom limiting self care ADL; assistive device indicated); 2 WHO CIPN grading (Grade 0 = None, Grade 1 = Paresthesias and/or decreased tendon reflexes, Grade 2 = severe paresthesias and/or mild weakness, Grade 3 = intolerable paresthesias and/or marked motor loss); 3 ECIPN-20 grading (Grade 1 = not at al, Grade 2 = a little, Grade 3 = quite a bit, Grade 4 = very much); 4 FACT GOG-Ntx grading (Grade 0 = not at all, Grade 1 = a little bit, Grade 2 = somewhat, Grade 3 = quite a bit, Grade 4 = very much). Bold font and underlined numbers indicate the highest prevalence of peripheral neuropathy for each measure used
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us