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Table 2 Chemotherapy-induced peripheral neuropathy prevalence by different measures over time (N = 343)

From: Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy

Measures Baseline Cycle1 Cycle2 Cycle3 Cycle4 Cycle5 Cycle6 6mFU 9mFU 12mFU
n/N % n/N % n/N % n/N % n/N % n/N % n/N % n/N % n/N % n/N %
NCI motor1
 Grade 1 338/341 99.1 294/308 95.5 273/290 94.1 244/273 89.4 209/242 86.4 121/142 85.2 99/120 82.5 219/255 85.9 204/234 87.2 177/194 91.2
 Grade > =2 3/341 0.9 14/308 4.5 17/290 5.9 29/273 10.6 33/242 13.6 21/142 14.8 21/120 17.5 36/255 14.1 30/234 12.8 17/194 8.8
Grade 2 3/341 0.9 14/308 4.5 16/290 5.5 25/273 9.2 28/242 11.6 17/142 12.0 18/120 15.0 26/255 10.2 25/234 10.7 14/194 7.2
Grade 3      1/290 0.4 4/273 1.5 5/242 2.1 4/142 2.8 3/120 2.5 10/255 3.9 5/234 2.1 3/194 1.6
NCI sensory1
 Grade 1 340/341 99.7 297/308 96.4 273/290 94.1 254/273 93.0 222/242 91.7 126/142 88.7 103/120 85.8 222/255 87.1 205/233 88.0 178/194 91.8
 Grade > =2 1/341 0.3 11/308 3.6 17/290 5.9 19/273 7.0 20/242 8.3 16/142 11.3 17/120 14.2 33/255 12.9 28/233 12.0 16/194 8.2
Grade 2 1/341 0.3 11/308 3.6 16/290 5.5 13/273 4.8 17/242 7.0 14/142 9.9 16/120 13.3 28/255 11.0 26/233 11.2 14/194 7.2
Grade 3      1/290 0.4 6/273 2.2 3/242 1.2 2/142 1.4 1/120 0.8 5/255 2.0 2/233 0.8 2/194 1.0
WHO CIPN 2
 Grade 0 333/341 97.7 277/308 89.9 248/290 85.5 217/273 79.5 182/242 75.2 99/142 69.7 97/120 80.8 210/255 82.4 197/234 84.2 180/194 92.8
 Grade > = 1 8/341 2.3 31/308 10.1 42/290 14.5 56/273 20.5 60/242 24.8 43/142 30.3 23/120 19.2 45/255 17.6 37/234 15.8 14/194 7.2
Grade 1 8/341 2.3 25/308 8.1 37/290 12.8 49/273 17.9 53/242 21.9 39/142 27.5 21/120 17.5 40/255 15.7 33/234 14.1 12/194 6.2
Grade 2    5/308 1.6 3/290 1.0 6/273 2.2 7/242 2.9 3/142 2.1 2/120 1.6 5/255 2.0 4/234 1.7 2/194 1.0
Grade 3    1/308 0.3 2/290 0.7 1/273 0.4    1/142 0.7         
Cotton wool
 Normal (−) 306/307 99.7 268/279 96.1 257/267 96.3 237/257 92.2 203/212 95.8 124/135 91.9 100/107 93.5 188/217 86.6 163/183 89.1 138/143 96.5
 Abnormal (+) 1/307 0.3 11/279 3.9 10/267 3.7 20/257 7.8 9/212 4.2 11/135 8.1 7/107 6.5 29/217 13.4 20/183 10.9 5/143 3.5
A lot of sensation    4/279 1.4 8/267 3.0 2/257 0.8      3/107 2.8 3/217 1.4 6/183 3.3 1/143 0.7
A bit sensation 1/307 0.3 1/279 0.4 1/267 0.4 2/257 0.8 2/212 0.9 1/135 0.7    21/217 9.7 12/183 6.6 4/143 2.8
No sensation    6/279 2.2 1/267 0.4 16/257 6.2 7/212 3.3 10/135 7.4 4/107 3.7 5/217 2.3 2/183 1.1   
Monofilament
 Normal (−) 306/307 99.7 290/302 96.0 272/290 93.8 246/273 90.1 198/220 90.0 121/142 85.2 92/106 86.8 187/232 80.6 162/196 82.7 137/147 93.2
 Abnormal (+) 1/307 0.3 12/302 4.0 18/290 6.2 27/273 9.9 22/220 10.0 21/142 14.8 14/106 13.2 45/232 19.4 34/196 17.3 10/147 6.9
A lot of sensation    2/302 0.7 3/290 1.0 4/273 1.5 2/220 0.9 4/142 2.8    5/232 2.2 9/196 4.6 2/147 1.4
A bit sensation 1/307 0.3 5/302 1.7 8/290 2.8 11/273 4.0 14/220 6.4 9/142 6.3 9/106 8.5 33/232 14.2 21/196 10.7 7/147 4.8
No sensation    5/302 1.7 7/290 2.4 12/273 4.4 6/220 2.7 8/142 5.6 5/106 4.7 7/232 3.0 4/196 2.1 1/147 0.7
ECIPN-20 3
 Numbness in hands/fingers
Grade 1 286/342 83.6 232/306 75.8 198/287 69.0 176/271 64.9 144/240 60.0 82/138 59.4 55/118 46.6 142/255 55.7 146/234 62.4 134/195 68.8
Grade > =2 56/342 16.4 74/306 24.2 89/287 31.0 95/271 35.1 96/240 40.0 56/138 40.6 63/118 53.4 113/255 44.3 88/234 37.6 61/195 31.2
Grade 2 50/342 14.6 55/306 18.0 62/287 21.6 72/271 26.6 66/240 27.5 36/138 26.1 36/118 30.5 73/255 28.6 67/234 28.6 49/195 25.1
Grade 3 5/342 1.5 12/306 3.9 21/287 7.3 16/271 5.9 21/240 8.8 14/138 10.1 19/118 16.1 27/255 10.6 16/234 6.8 9/195 4.6
Grade 4 1/342 0.3 7/306 2.3 6/287 2.1 7/271 2.6 9/240 3.8 6/138 4.3 8/118 6.8 13/255 5.1 5/234 2.1 3/195 1.5
Numbness in feet/toes
Grade 1 308/343 89.8 244/307 79.5 217/287 75.6 188/271 69.4 146/240 60.8 81/138 58.7 65/118 55.1 142/255 55.7 148/235 63.0 138/195 70.8
Grade > =2 35/343 10.2 63/307 20.5 70/287 24.4 83/271 30.6 94/240 39.2 57/138 41.3 53/118 44.9 113/255 44.3 87/235 37.0 57/195 29.2
Grade 2 31/343 9.0 49/307 16.0 47/287 16.4 62/271 22.9 65/240 27.1 37/138 26.8 36/118 30.5 73/255 28.6 63/235 26.8 41/195 21.0
Grade 3 2/343 0.6 10/307 3.3 16/287 5.6 12/271 4.4 22/240 9.2 13/138 9.4 12/118 10.2 29/255 11.4 16/235 6.8 11/195 5.6
Grade 4 2/343 0.6 4/307 1.3 7/287 2.4 9/271 3.3 7/240 2.9 7/138 5.1 5/118 4.2 11/255 4.3 8/235 3.4 5/195 2.6
FACTGOG-Ntx 4
Numbness/tingling in hands
Grade 0 296/343 86.3 235/307 76.5 194/287 67.6 178/271 65.7 144/240 60.0 75/138 54.3 60/119 50.4 139/255 54.5 148/235 63.0 137/195 70.3
Grade > =1 47/343 13.7 72/307 23.5 93/287 32.4 93/271 34.3 96/240 40.0 63/138 45.7 59/119 49.6 116/255 45.5 87/235 37.0 58/195 29.7
Grade 1 39/343 11.4 42/307 13.7 57/287 19.9 61/271 22.5 61/240 25.4 36/138 26.1 33/119 27.7 65/255 25.5 61/235 26.0 37/195 19.0
Grade 2 4/343 1.2 17/307 5.5 12/287 4.2 10/271 3.7 15/240 6.3 8/138 5.8 14/119 11.8 18/255 7.1 9/235 3.8 8/195 4.1
Grade 3 2/343 0.6 9/307 2.9 12/287 4.2 11/271 4.1 14/240 5.8 12/138 8.7 7/119 5.9 20/255 7.8 11/235 4.7 9/195 4.6
Grade 4 2/343 0.6 4/307 1.3 12/287 4.2 11/271 4.1 6/240 2.5 7/138 5.1 5/119 4.2 13/255 5.1 6/235 2.6 4/195 2.1
Numbness/tingling in feet
Grade 0 317/343 92.4 247/307 80.5 215/287 74.9 183/271 67.5 146/240 60.8 79/138 57.2 70/118 59.3 137/255 53.7 150/235 63.8 143/195 73.3
Grade > =1 26/343 7.6 60/307 19.5 72/287 25.1 88/271 32.5 94/240 39.2 59/138 42.8 48/118 40.7 118/255 46.3 85/235 36.2 52/195 26.7
Grade 1 17/343 5.0 35/307 11.4 44/287 15.3 58/271 21.4 65/240 27.1 35/138 25.4 30/118 25.4 69/255 27.1 54/235 23.0 34/195 17.4
Grade 2 6/343 1.7 12/307 3.9 10/287 3.5 9/271 3.3 13/240 5.4 5/138 3.6 9/118 7.6 22/255 8.6 13/235 5.5 7/195 3.6
Grade 3 2/343 0.6 7/307 2.3 10/287 3.5 11/271 4.1 10/240 4.2 13/138 9.4 6/118 5.1 17/255 6.7 9/235 3.8 9/195 4.6
Grade 4 1/343 0.3 6/307 2.0 8/287 2.8 10/271 3.7 6/240 2.5 6/138 4.3 3/118 2.5 10/255 3.9 9/235 3.8 2/195 1.0
  1. 1NCI sensory/motor grading (Grade 1 = Asymptomatic not interfering with functioning, Grade 2 = Moderate symptoms limiting instrumental ADL, Grade 3 = Severe symptom limiting self care ADL; assistive device indicated); 2 WHO CIPN grading (Grade 0 = None, Grade 1 = Paresthesias and/or decreased tendon reflexes, Grade 2 = severe paresthesias and/or mild weakness, Grade 3 = intolerable paresthesias and/or marked motor loss); 3 ECIPN-20 grading (Grade 1 = not at al, Grade 2 = a little, Grade 3 = quite a bit, Grade 4 = very much); 4 FACT GOG-Ntx grading (Grade 0 = not at all, Grade 1 = a little bit, Grade 2 = somewhat, Grade 3 = quite a bit, Grade 4 = very much). Bold font and underlined numbers indicate the highest prevalence of peripheral neuropathy for each measure used