Table 1 Clinical and primary tumor characteristics of the overall population at MBC diagnosis (N = 379)
Characteristic | N (%) | |
|---|---|---|
Caucasians | 371 (99.2) | |
Median age at MBC diagnosis, years | 61.2 (50.7–70.9) | |
BMI at MBC diagnosis (kg/m2), median (IQR) (N = 320) | 27.0 (23.9–31.4) | |
BMI category at MBC diagnosis (N = 320) | Underweight (BMI < 18.5 kg/m 2 ) | 2 (0.6) |
Normal (BMI ≥ 18.5 and BMI < 25 kg/m 2 ) | 117 (36.6) | |
Overweight (BMI ≥ 25 and BMI < 30 kg/m 2 ) | 102 (31.9) | |
Obese (BMI ≥ 30 kg/m 2 ) | 99 (30.9) | |
Menopausal status at MBC diagnosis (N = 330) | Postmenopausal | 256 (77.6) |
Premenopausal | 66 (20.0) | |
Perimenopausal | 8 (2.5) | |
Use of oral contraceptives (N = 236) | 9 (3.8) | |
Use of hormone replacement therapy (N = 238) | 10 (4.2) | |
Family history of breast cancer (N = 323) | 47 (14.6) | |
Family history of ovarian cancer (N = 322) | 5 (1.6) | |
Comorbidities at MBC diagnosisa (N = 379) | Vascular disorders | 61 (16.1) |
Cardiac disorders | 51 (13.5) | |
Endocrine disorders | 50 (13.2) | |
Psychiatric disorders | 24 (6.3) | |
Metabolism and nutrition disorders | 22 (5.8) | |
ECOG performance status at MBC diagnosis (N = 374) | PS 0–1 | 344 (92.0) |
PS 2–3 | 30 (8.0) | |
Primary tumor location (N = 376) | Left breast | 189 (50.3) |
Right breast | 179 (47.6) | |
Both breasts | 8 (2.1) | |
Primary tumor size (N = 301) | Tumor size ≤ 2 cm | 110 (36.5) |
2 cm < tumor size ≤ 5 cm | 148 (49.2) | |
Tumor size > 5 cm | 43 (14.3) | |
Number of metastases at MBC diagnosis, median (IQR) (N = 264 b) | 2.0 (1.0–3.0) | |
Distant metastatic sites (N = 369)a | Bones | 207 (56.1) |
Lung | 138 (37.4) | |
Liver | 106 (28.7) | |
Lymph nodes | 70 (19.0) | |
Brain | 35 (9.5) | |
Pleural effusion | 29 (7.9) | |