Table 1 Predictive values for the presence of BM of serum CEA, CA 15–3, T-Tau, HER2 ECD and MMP-9 (A) in univariate and (B) multivariate analyses

Total (n = 244)

BM (n = 86)

No BM (n = 158)

P-value

(n = 226)

4.0 (1.0–5122.0)

62.02 (358.1)

(n = 81)

9.0 (1.0–5122.0)

122.72 (582.7)

(n = 145)

3.0 (1.0–768.0)

28.12 (92.1)

0.025

(n = 226)

37.5 (8.0–1988.0)

177.27 (337.6)

(n = 81)

48.0 (11.0–1549.0)

210.92 (324.8)

(n = 145)

34.0 (8.0–1988.0)

158.48 (344.3)

0.157

(n = 244)

1.24 (0.0–755.5)

18.70 (92.2)

(n = 86)

1.56 (0.0–751.1)

30.60 (120.4)

(n = 158)

1.16 (0.0–755.5)

12.22 (72.1)

0.232

(n = 244)

14.00 (2.8–280)

36.87 (58.10)

(n = 86)

21.30 (2.8–280)

49.01 (68.20)

(n = 158)

12.15 (5.7–280)

30.26 (50.90)

0.077

(n = 244)

333.80 (38.7–2051)

415.43 (300.70)

(n = 86)

416.08 (38.7–1575.8)

463.83 (292.2)

(n = 158)

317.00 (39–2051)

389.08 (302.8)

0.066

Hazard-ratio

95%CI

P-value

2.71

1.10–6.68

0.030

0.33

0.14–0.78

0.012

3.98

1.11–14.30

0.034

7.26

2.32–22.71

0.001

4.69

2.05–10.73

< 0.001