Table 3 Trends in transitional cell carcinoma of the bladder Incidence-based mortality Rates (1973–2014)
|  | Overall (1973–2014) | Trends | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
APCa (95% CI) | P valueb | year | APCa (95% CI) | P valueb | year | APCa (95% CI) | P valueb | year | APCa (95% CI) | P valueb | |
Overall | −0.57 (− 1.27–0.14) | .12 | 1973–1975 | 15.38 (8.07–23.20) | <.001 | 1975–1987 | 2.66 (2.28–3.04) | <.001 | 1987–1999 | −0.06 (− 0.39–0.27) | .72 |
1999–2008 | − 3.90 (− 4.48 - -3.31) | <.001 | 2008–2012 | − 12.03 (− 14.94 - -9.02) | <.001 | 2012–2014 | − 42.88 (− 49.35 - -35.59) | <.001 | |||
Sex | |||||||||||
 Male | −0.45 (− 1.18–0.29) | .22 | 1973–1975 | 14.93 (6.75–23.73) | .001 | 1975–1987 | 2.97 (2.53–3.40) | <.001 | 1987–1999 | − 0.01 (− 0.40–0.39) | .96 |
1999–2008 | − 3.57 (− 4.23 - -2.91) | <.001 | 2008–2012 | − 13.15 (− 16.55 - -9.61) | <.001 | 2012–2014 | − 43.51 (− 50.84 - -35.09) | <.001 | |||
 Female | −0.68 (− 1.38–0.02) | .06 | 1973–1976 | 14.12 (5.50–23.45) | .002 | 1976–1993 | 1.69 (1.18–2.19) | <.001 | 1993–2004 | − 2.05 (− 3.02 - -1.07) | <.001 |
2004–2012 | − 7.70 (− 9.55 - -5.80) | <.001 | 2012–2014 | − 39.61 (− 55.68 - -17.72) | .002 |  |  |  | |||
Race | |||||||||||
 Caucasians | − 0.74 (− 1.47–0.001) | .05 | 1973–1975 | 15.96 (8.94–23.44) | <.001 | 1975–1987 | 2.53 (2.17–2.90) | <.001 | 1987–1999 | − 0.27 (− 0.59–0.06) | .10 |
1999–2008 | − 4.07 (− 4.65 - -3.48) | <.001 | 2008–2012 | − 12.43 (− 15.50 - -9.25) | <.001 | 2012–2014 | − 44.00 (− 50.11 - -37.14) | <.001 | |||
 African Americans | 0.68 (− 0.10–1.46) | .09 | 1973–1976 | 25.72 (6.28–48.70) | .01 | 1976–1991 | 3.66 (2.50–4.83) | <.001 | 1991–2004 | − 0.04 (− 1.30–1.23) | .95 |
2004–2012 | − 5.41 (− 8.38 - -2.34) | .001 | 2012–2014 | − 35.17 (− 54.87–6.88) | .02 |  |  |  | |||
 Othersc | 1.68 (0.77–2.60) | .001 | 1973–1998 | 4.66 (3.83–5.50) | <.001 | 1998–2008 | −1.55 (− 4.26–1.24) | .26 | 2008–2014 | −14.68 (− 20.74 - -8.17) | <.001 |
Age at death, y | |||||||||||
 20–44 | −0.61 (−1.60–0.40) | .23 | 1973–1987 | 5.55 (1.54–9.73) | .01 | 1987–2014 | − 2.50 (− 3.91 - -1.08) | .001 |  |  |  |
 45–64 | − 0.52 (− 0.91 - -0.13) | .01 | 1973–2007 | −0.08 (− 0.34–0.17) | .51 | 2007–2012 | −4.91 (− 11.30–1.94) | .15 | 2012–2014 | − 43.37 (− 63.12 - -13.06) | .01 |
 65–84 | − 0.85 (− 1.55 - -0.14) | .02 | 1973–1975 | 15.94 (7.25–25.34) | .001 | 1975–1988 | 2.31 (1.91–2.70) | <.001 | 1988–1999 | − 0.63 (− 1.11 - -0.14) | .01 |
1999–2008 | − 4.30 (− 5.02 - -3.57) | <.001 | 2008–2012 | − 12.41 (− 16.18 - -8.47) | <.001 | 2012–2014 | − 41.48 (− 50.01 - -31.50) | <.001 | |||
  > 84 | −0.10 (− 0.90–0.71) | .81 | 1973–1975 | 20.02 (5.72–36.27) | .01 | 1975–1987 | 3.81 (3.12–4.50) | <.001 | 1987–2001 | 0.27 (− 0.19–0.74) | .24 |
2001–2008 | − 5.03 (− 6.56 - -3.48) | <.001 | 2008–2012 | − 12.13 (− 17.30 - -6.62) | <.001 | 2012–2014 | − 44.00 (− 55.10 - -30.16) | <.001 | |||
Stage at diagnosisd | |||||||||||
 Localized | −0.79 (−1.60–0.03) | .06 | 1973–1975 | 14.15 (4.78–24.37) | .004 | 1975–1987 | 2.91 (2.41–3.42) | <.001 | 1987–2000 | −0.36 (− 0.75–0.04) | .08 |
2000–2008 | −5.55 (− 6.48 - -4.62) | <.001 | 2008–2012 | −17.14 (− 21.68 - -12.35) | <.001 | 2012–2014 | −48.97 (− 59.18 - -36.19) | <.001 | |||
 Regional | 0.43 (− 0.16–1.03) | .15 | 1973–1976 | 25.65 (14.69–37.67) | <.001 | 1976–2000 | 1.23 (0.88–1.58) | <.001 | 2000–2012 | − 2.39 (− 3.39 - -1.38) | <.001 |
2012–2014 | − 44.00 (− 57.08 - -26.94) | <.001 |  |  |  |  |  |  | |||
 Distant | 2.43 (2.06–2.80) | <.001 | 1973–1976 | 25.75 (1.88–55.20) | .03 | 1976–1997 | 1.47 (0.67–2.27) | .001 | 1997–2012 | 3.97 (2.66–5.29) | <.001 |
2012–2014 | −24.63 (− 46.37–5.93) | .10 |  |  |  |  |  |  | |||