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Table 3 Trends in transitional cell carcinoma of the bladder Incidence-based mortality Rates (1973–2014)

From: Trends in the incidence and mortality of transitional cell carcinoma of the bladder for the last four decades in the USA: a SEER-based analysis

  Overall (1973–2014) Trends
APCa (95% CI) P valueb year APCa (95% CI) P valueb year APCa (95% CI) P valueb year APCa (95% CI) P valueb
Overall −0.57 (− 1.27–0.14) .12 1973–1975 15.38 (8.07–23.20) <.001 1975–1987 2.66 (2.28–3.04) <.001 1987–1999 −0.06 (− 0.39–0.27) .72
1999–2008 − 3.90 (− 4.48 - -3.31) <.001 2008–2012 − 12.03 (− 14.94 - -9.02) <.001 2012–2014 − 42.88 (− 49.35 - -35.59) <.001
Sex
 Male −0.45 (− 1.18–0.29) .22 1973–1975 14.93 (6.75–23.73) .001 1975–1987 2.97 (2.53–3.40) <.001 1987–1999 − 0.01 (− 0.40–0.39) .96
1999–2008 − 3.57 (− 4.23 - -2.91) <.001 2008–2012 − 13.15 (− 16.55 - -9.61) <.001 2012–2014 − 43.51 (− 50.84 - -35.09) <.001
 Female −0.68 (− 1.38–0.02) .06 1973–1976 14.12 (5.50–23.45) .002 1976–1993 1.69 (1.18–2.19) <.001 1993–2004 − 2.05 (− 3.02 - -1.07) <.001
2004–2012 − 7.70 (− 9.55 - -5.80) <.001 2012–2014 − 39.61 (− 55.68 - -17.72) .002    
Race
 Caucasians − 0.74 (− 1.47–0.001) .05 1973–1975 15.96 (8.94–23.44) <.001 1975–1987 2.53 (2.17–2.90) <.001 1987–1999 − 0.27 (− 0.59–0.06) .10
1999–2008 − 4.07 (− 4.65 - -3.48) <.001 2008–2012 − 12.43 (− 15.50 - -9.25) <.001 2012–2014 − 44.00 (− 50.11 - -37.14) <.001
 African Americans 0.68 (− 0.10–1.46) .09 1973–1976 25.72 (6.28–48.70) .01 1976–1991 3.66 (2.50–4.83) <.001 1991–2004 − 0.04 (− 1.30–1.23) .95
2004–2012 − 5.41 (− 8.38 - -2.34) .001 2012–2014 − 35.17 (− 54.87–6.88) .02    
 Othersc 1.68 (0.77–2.60) .001 1973–1998 4.66 (3.83–5.50) <.001 1998–2008 −1.55 (− 4.26–1.24) .26 2008–2014 −14.68 (− 20.74 - -8.17) <.001
Age at death, y
 20–44 −0.61 (−1.60–0.40) .23 1973–1987 5.55 (1.54–9.73) .01 1987–2014 − 2.50 (− 3.91 - -1.08) .001    
 45–64 − 0.52 (− 0.91 - -0.13) .01 1973–2007 −0.08 (− 0.34–0.17) .51 2007–2012 −4.91 (− 11.30–1.94) .15 2012–2014 − 43.37 (− 63.12 - -13.06) .01
 65–84 − 0.85 (− 1.55 - -0.14) .02 1973–1975 15.94 (7.25–25.34) .001 1975–1988 2.31 (1.91–2.70) <.001 1988–1999 − 0.63 (− 1.11 - -0.14) .01
1999–2008 − 4.30 (− 5.02 - -3.57) <.001 2008–2012 − 12.41 (− 16.18 - -8.47) <.001 2012–2014 − 41.48 (− 50.01 - -31.50) <.001
  > 84 −0.10 (− 0.90–0.71) .81 1973–1975 20.02 (5.72–36.27) .01 1975–1987 3.81 (3.12–4.50) <.001 1987–2001 0.27 (− 0.19–0.74) .24
2001–2008 − 5.03 (− 6.56 - -3.48) <.001 2008–2012 − 12.13 (− 17.30 - -6.62) <.001 2012–2014 − 44.00 (− 55.10 - -30.16) <.001
Stage at diagnosisd
 Localized −0.79 (−1.60–0.03) .06 1973–1975 14.15 (4.78–24.37) .004 1975–1987 2.91 (2.41–3.42) <.001 1987–2000 −0.36 (− 0.75–0.04) .08
2000–2008 −5.55 (− 6.48 - -4.62) <.001 2008–2012 −17.14 (− 21.68 - -12.35) <.001 2012–2014 −48.97 (− 59.18 - -36.19) <.001
 Regional 0.43 (− 0.16–1.03) .15 1973–1976 25.65 (14.69–37.67) <.001 1976–2000 1.23 (0.88–1.58) <.001 2000–2012 − 2.39 (− 3.39 - -1.38) <.001
2012–2014 − 44.00 (− 57.08 - -26.94) <.001       
 Distant 2.43 (2.06–2.80) <.001 1973–1976 25.75 (1.88–55.20) .03 1976–1997 1.47 (0.67–2.27) .001 1997–2012 3.97 (2.66–5.29) <.001
2012–2014 −24.63 (− 46.37–5.93) .10       
  1. a Annual Percentage Changes, calculated using Joinpoint regression software
  2. b Two-sided P value was calculated using t test to determine the significance of APC change
  3. c Includes American Indian/Alaskan Native and Asian/Pacific Islander
  4. d using SEER historic stage A
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