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Table 2 Trends in transitional cell carcinoma of the bladder Incidence Rates (1973–2014)

From: Trends in the incidence and mortality of transitional cell carcinoma of the bladder for the last four decades in the USA: a SEER-based analysis

 

Overall (1973–2014)

Trends

1

2

3

APCa (95% CI)

P valueb

year

APCa (95% CI)

P valueb

year

APCa (95% CI)

P valueb

year

APCa (95% CI)

P valueb

Overall

0.16 (0.02–0.30)

.02

1973–1987

1.45 (1.17–1.72)

<.001

1987–2007

−0.04 (− 0.17–0.10)

.61

2007–2014

− 1.33 (− 1.89 - -0.77)

<.001

Sex

 Male

0.02 (− 0.08–0.22)

.37

1973–1987

1.54 (1.24–1.85)

<.001

1987–2007

− 0.17 (− 0.31 - -0.02)

.03

2007–2014

− 1.47 (− 2.06 - -0.88)

<.001

 Female

0.05 (− 0.12–0.22)

.56

1973–1976

6.36 (− 0.35–13.51)

.06

1976–1999

0.54 (0.31–0.78)

<.001

1999–2014

− 1.05 (− 1.40 - -0.70)

<.001

Race

 Caucasian

0.30 (0.15–0.44)

<.001

1973–1987

1.64 (1.36–1.91)

<.001

1987–2007

0.09 (− 0.05–0.23)

.19

2007–2014

− 1.33 (− 1.90 - -0.76)

<.001

 African American

0.51 (0.27–0.75)

<.001

1973–2014

0.51 (0.27–0.75)

<.001

      

 Othersc

0.13 (− 0.15–0.40)

.35

1973–2004

0.60 (0.16–1.04)

.01

2004–2014

− 1.34 (− 2.69–0.03)

.06

   

Age at diagnosis, y

 20–44

− 1.61 (− 1.85 - -1.36)

<.001

1973–1981

2.25 (0.08–4.46)

.04

1981–2014

− 1.99 (− 2.22 - -1.76)

<.001

   

 45–64

−0.64 (− 0.86 - -0.41)

<.001

1973–1986

1.65 (1.24–2.06)

<.001

1986–1999

−0.74 (− 1.15 - -0.34)

.001

1999–2014

− 1.90 (− 2.16 - -1.64)

<.001

 65–84

0.53 (0.38–0.67)

<.001

1973–1991

1.42 (1.17–1.66)

<.001

1991–2007

0.29 (0.04–0.54)

.03

2007–2014

− 1.18 (− 1.91 - -0.44)

.003

  > 84

0.56(0.41–0.70)

<.001

1973–2000

0.13 (− 0.15–0.41)

.35

2000–2003

4.39 (− 7.05–17.23)

.46

2003–2014

0.01 (− 0.67–0.70)

.98

Stage at diagnosisd

 Localized

0.37 (0.22–0.52)

<.001

1973–1986

1.76 (1.38–2.13)

<.001

1986–2005

0.32 (0.15–0.50)

.001

2005–2014

− 1.07 (− 1.52 - -0.63)

<.001

 Regional

−0.18 (− 0.39–0.02)

.08

1973–1976

14.96 (5.51–25.25)

.002

1976–2000

0.02 (− 0.24–0.29)

.86

2000–2014

− 1.10 (− 1.57 - -0.61)

<.001

 Distant

1.02 (0.72–1.31)

<.001

1973–2014

1.02 (0.72–1.31)

<.001

      
  1. a Annual Percentage Changes, calculated using Joinpoint regression software
  2. b Two-sided P value was calculated using t test to determine the significance of APC change
  3. c Includes American Indian/Alaskan Native and Asian/Pacific Islander
  4. d using SEER historic stage A