| Overall (1973–2014) | Trends | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | |||||||||
APCa (95% CI) | P valueb | year | APCa (95% CI) | P valueb | year | APCa (95% CI) | P valueb | year | APCa (95% CI) | P valueb | |
Overall | 0.16 (0.02–0.30) | .02 | 1973–1987 | 1.45 (1.17–1.72) | <.001 | 1987–2007 | −0.04 (− 0.17–0.10) | .61 | 2007–2014 | − 1.33 (− 1.89 - -0.77) | <.001 |
Sex | |||||||||||
 Male | 0.02 (− 0.08–0.22) | .37 | 1973–1987 | 1.54 (1.24–1.85) | <.001 | 1987–2007 | − 0.17 (− 0.31 - -0.02) | .03 | 2007–2014 | − 1.47 (− 2.06 - -0.88) | <.001 |
 Female | 0.05 (− 0.12–0.22) | .56 | 1973–1976 | 6.36 (− 0.35–13.51) | .06 | 1976–1999 | 0.54 (0.31–0.78) | <.001 | 1999–2014 | − 1.05 (− 1.40 - -0.70) | <.001 |
Race | |||||||||||
 Caucasian | 0.30 (0.15–0.44) | <.001 | 1973–1987 | 1.64 (1.36–1.91) | <.001 | 1987–2007 | 0.09 (− 0.05–0.23) | .19 | 2007–2014 | − 1.33 (− 1.90 - -0.76) | <.001 |
 African American | 0.51 (0.27–0.75) | <.001 | 1973–2014 | 0.51 (0.27–0.75) | <.001 |  |  |  |  |  |  |
 Othersc | 0.13 (− 0.15–0.40) | .35 | 1973–2004 | 0.60 (0.16–1.04) | .01 | 2004–2014 | − 1.34 (− 2.69–0.03) | .06 |  |  |  |
Age at diagnosis, y | |||||||||||
 20–44 | − 1.61 (− 1.85 - -1.36) | <.001 | 1973–1981 | 2.25 (0.08–4.46) | .04 | 1981–2014 | − 1.99 (− 2.22 - -1.76) | <.001 |  |  |  |
 45–64 | −0.64 (− 0.86 - -0.41) | <.001 | 1973–1986 | 1.65 (1.24–2.06) | <.001 | 1986–1999 | −0.74 (− 1.15 - -0.34) | .001 | 1999–2014 | − 1.90 (− 2.16 - -1.64) | <.001 |
 65–84 | 0.53 (0.38–0.67) | <.001 | 1973–1991 | 1.42 (1.17–1.66) | <.001 | 1991–2007 | 0.29 (0.04–0.54) | .03 | 2007–2014 | − 1.18 (− 1.91 - -0.44) | .003 |
  > 84 | 0.56(0.41–0.70) | <.001 | 1973–2000 | 0.13 (− 0.15–0.41) | .35 | 2000–2003 | 4.39 (− 7.05–17.23) | .46 | 2003–2014 | 0.01 (− 0.67–0.70) | .98 |
Stage at diagnosisd | |||||||||||
 Localized | 0.37 (0.22–0.52) | <.001 | 1973–1986 | 1.76 (1.38–2.13) | <.001 | 1986–2005 | 0.32 (0.15–0.50) | .001 | 2005–2014 | − 1.07 (− 1.52 - -0.63) | <.001 |
 Regional | −0.18 (− 0.39–0.02) | .08 | 1973–1976 | 14.96 (5.51–25.25) | .002 | 1976–2000 | 0.02 (− 0.24–0.29) | .86 | 2000–2014 | − 1.10 (− 1.57 - -0.61) | <.001 |
 Distant | 1.02 (0.72–1.31) | <.001 | 1973–2014 | 1.02 (0.72–1.31) | <.001 |  |  |  |  |  |  |