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Table 2 Trends in transitional cell carcinoma of the bladder Incidence Rates (1973–2014)

From: Trends in the incidence and mortality of transitional cell carcinoma of the bladder for the last four decades in the USA: a SEER-based analysis

  Overall (1973–2014) Trends
1 2 3
APCa (95% CI) P valueb year APCa (95% CI) P valueb year APCa (95% CI) P valueb year APCa (95% CI) P valueb
Overall 0.16 (0.02–0.30) .02 1973–1987 1.45 (1.17–1.72) <.001 1987–2007 −0.04 (− 0.17–0.10) .61 2007–2014 − 1.33 (− 1.89 - -0.77) <.001
Sex
 Male 0.02 (− 0.08–0.22) .37 1973–1987 1.54 (1.24–1.85) <.001 1987–2007 − 0.17 (− 0.31 - -0.02) .03 2007–2014 − 1.47 (− 2.06 - -0.88) <.001
 Female 0.05 (− 0.12–0.22) .56 1973–1976 6.36 (− 0.35–13.51) .06 1976–1999 0.54 (0.31–0.78) <.001 1999–2014 − 1.05 (− 1.40 - -0.70) <.001
Race
 Caucasian 0.30 (0.15–0.44) <.001 1973–1987 1.64 (1.36–1.91) <.001 1987–2007 0.09 (− 0.05–0.23) .19 2007–2014 − 1.33 (− 1.90 - -0.76) <.001
 African American 0.51 (0.27–0.75) <.001 1973–2014 0.51 (0.27–0.75) <.001       
 Othersc 0.13 (− 0.15–0.40) .35 1973–2004 0.60 (0.16–1.04) .01 2004–2014 − 1.34 (− 2.69–0.03) .06    
Age at diagnosis, y
 20–44 − 1.61 (− 1.85 - -1.36) <.001 1973–1981 2.25 (0.08–4.46) .04 1981–2014 − 1.99 (− 2.22 - -1.76) <.001    
 45–64 −0.64 (− 0.86 - -0.41) <.001 1973–1986 1.65 (1.24–2.06) <.001 1986–1999 −0.74 (− 1.15 - -0.34) .001 1999–2014 − 1.90 (− 2.16 - -1.64) <.001
 65–84 0.53 (0.38–0.67) <.001 1973–1991 1.42 (1.17–1.66) <.001 1991–2007 0.29 (0.04–0.54) .03 2007–2014 − 1.18 (− 1.91 - -0.44) .003
  > 84 0.56(0.41–0.70) <.001 1973–2000 0.13 (− 0.15–0.41) .35 2000–2003 4.39 (− 7.05–17.23) .46 2003–2014 0.01 (− 0.67–0.70) .98
Stage at diagnosisd
 Localized 0.37 (0.22–0.52) <.001 1973–1986 1.76 (1.38–2.13) <.001 1986–2005 0.32 (0.15–0.50) .001 2005–2014 − 1.07 (− 1.52 - -0.63) <.001
 Regional −0.18 (− 0.39–0.02) .08 1973–1976 14.96 (5.51–25.25) .002 1976–2000 0.02 (− 0.24–0.29) .86 2000–2014 − 1.10 (− 1.57 - -0.61) <.001
 Distant 1.02 (0.72–1.31) <.001 1973–2014 1.02 (0.72–1.31) <.001       
  1. a Annual Percentage Changes, calculated using Joinpoint regression software
  2. b Two-sided P value was calculated using t test to determine the significance of APC change
  3. c Includes American Indian/Alaskan Native and Asian/Pacific Islander
  4. d using SEER historic stage A