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Table 1 Clinicopathological characteristics of the cholangiocarcinoma cohort

From: Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

   All cases PD-L1 (< 1%) PD-L1 (≥1%) p-value
Number (%) 170 (100) 151 (89) 19 (11)  
Age Range (years) 31–91 31–91 34–78 0.886 *
Median (years) 63 63 66  
<Median (total) 85 (50) 76 (45) 9 (5) 1.000 **
>Median (total) 85 (50) 75 (44) 10 (6)  
Sex male 109 (64) 94 (55) 15 (9) 0.206 **
female 61 (36) 57 (34) 4 (2)  
CCA subgroups iCCA 72 (42) 64 (38) 8 (5) 0.967 ***
pCCA 57 (34) 51 (30) 6 (4)  
dCCA 41 (24) 36 (21) 5 (3)  
UICC stage# UICC 1 6 (4) 6 (4) 0 (0) 0.481 ***
UICC 2 62 (36) 56 (33) 6 (4)  
UICC 3 45 (26) 37 (22) 8 (5)  
UICC 4 16 (9) 14 (8) 2 (1)  
NA 41 (24) 38 (22) 3 (2)  
pT T1 21 (12) 19 (11) 2 (1) 0.183 ***
T2 91 (54) 83 (49) 8 (5)  
T3 44 (26) 39 (23) 5 (3)  
T4 14 (8) 10 (6) 4 (2)  
pN N0 53 (31) 49 (29) 4 (2) 0.267 **
N1 72 (42) 61 (36) 11 (6)  
NX 45 (26) 41 (24) 4 (2)  
M M0 153 (90) 136 (80) 17 (10) 1.000 **
M1 16 (9) 15 (9) 1 (1)  
NA 1 (1) 0 (0) 1 (1)  
G G1 8 (5) 6 (4) 2 (1) 0.135 ***
G2 121 (71) 111 (65) 10 (6)  
G3 41 (24) 34 (20) 7 (4)  
L L0 86 (51) 78 (46) 8 (5) 0.474 **
L1 84 (49) 73 (43) 11 (6)  
V V0 125 (74) 111 (65) 14 (8) 1.000 **
V1 45 (26) 40 (24) 5 (3)  
Pn Pn0 97 (57) 87 (51) 10 (6) 0.807 **
Pn1 73 (43) 64 (38) 9 (5)  
R R0 76 (45) 63 (37) 13 (8) 0.109 ***
R1 56 (33) 53 (31) 3 (2)  
R2 12 (7) 11 (6) 1 (1)  
Rx 26 (15) 24 (14) 2 (1)  
  1. * Mann-Whitney U-test; ** Fisher’s exact test; *** Chi-square test
  2. # Cases with pNX had no lymph nodes resected, therefore, UICC status could not be assessed
  3. iCCA intrahepatic cholangiocarcinoma, pCCA perihilar cholangiocarcinoma, dCCA distal cholangiocarcinoma, NA not available
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