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Fig. 7 | BMC Cancer

Fig. 7

From: miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα

Fig. 7

IκBα was a target of the miR-196a-5p. a The predicted seed region of IκBα bound to miR-196a-5p and the mutated sequence used in present work was shown at left. The luciferase activity was measured at 48 h after HEK293 cells cotransfected with vector/miR-196a-5p mimic, IκBα-WT/miR-196a-5p mimic or IκBα-WT/miR-196a-5p-mutant plasmid. b The expression of IκBα mRNA in CRC cells after transfection. c The effects of miR-196a-5p on the expression of IκBα and nuclear p65 were determined by western blot. Data were shown as mean ± SD, ***P < 0.001, **P < 0.01 and *P < 0.05 compared to NC group

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