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Table 2 Differences between HER2 evaluation in tumors of the upper gastrointestinal tract and breast cancer

From: HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma

  Tumors of the upper gastrointestinal tract Breast cancer
Threshold ≥ 5 positive tumor cells of biopsies; ≥ 10% surgical specimen ≥ 10% positive tumor cells
Expression pattern (baso)-lateral circular