Table 3 The genotype and allele frequencies of seven 3′UTR polymorphisms in lung cancer patients and controls
Gene | SNP ID | Genotype | Allele | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adjusted analysis | Crude analysis | ||||||||||||
Control | Case | OR (95% CI) | p | OR (95% CI) | p | Control | Case | OR (95% CI) | p | ||||
NR5A2 | rs1056426 | TT | 222 (57.8%) | 197 (61.6%) | 1.00 | 0.270 | 1.00 | T | 585 (76.2%) | 496 (77.5%) | 1.00 | 0.560 | |
CT | 141 (36.7%) | 102 (31.9%) | 0.78 (0.55–1.09) | 0.82 (0.59–1.12) | 0.380 | C | 183 (23.8%) | 144 (22.5%) | 0.93(0.72–1.19) | ||||
CC | 21 (5.5%) | 21 (6.6%) | 1.15 (0.59–2.24) | 1.13 (0.60–2.13) | |||||||||
NR5A2 | rs2246209 | GG | 184 (47.9%) | 160 (49.7%) | 1.00 | 0.940 | 1.00 | G | 528 (68.8%) | 450 (69.9%) | 1.00 | 0.650 | |
GA | 160 (41.7%) | 130 (40.4%) | 0.98 (0.70–1.37) | 0.93 (0.68–1.28) | 0.890 | A | 240 (31.3%) | 194 (30.1%) | 0.95(0.76–1.19) | ||||
AA | 40 (10.4%) | 32 (9.9%) | 0.91 (0.53–1.56) | 0.92 (0.55–1.53) | |||||||||
LPP | rs1064607 | GG | 157 (40.9%) | 111 (34.6%) | 1.00 | 0.280 | 1.00 | G | 488 (63.5%) | 382 (59.5%) | 1.00 | 0.120 | |
GC | 174 (45.3%) | 160 (49.8%) | 1.25 (0.89–1.77) | 1.30 (0.94–1.80) | 0.230 | C | 280 (36.5%) | 260 (40.5%) | 1.19(0.96–1.47) | ||||
CC | 53 (13.8%) | 50 (15.6%) | 1.41 (0.87–2.30) | 1.33 (0.85–2.11) | |||||||||
LPP | rs3796283 | AA | 134 (34.9%) | 94 (29.3%) | 1.00 | 0.490 | 1.00 | A | 450 (58.6%) | 355 (55.3%) | 1.00 | 0.210 | |
GA | 182 (47.4%) | 167 (52%) | 1.24 (0.86–1.77) | 1.31 (0.93–1.83) | 0.280 | G | 318 (41.4%) | 287 (44.7%) | 1.14(0.93–1.41) | ||||
GG | 68 (17.7%) | 60 (18.7%) | 1.20 (0.76–1.92) | 1.26 (0.81–1.95) | |||||||||
LPP | rs2378456 | GG | 117 (30.6%) | 88 (27.9%) | 1.00 | 0.890 | 1.00 | G | 419 (54.7%) | 333 (52.7%) | 1.00 | 0.450 | |
GC | 185 (48.3%) | 157 (49.7%) | 1.08 (0.74–1.56) | 1.13 (0.80–1.60) | 0.730 | C | 347 (45.3%) | 299 (47.3%) | 1.08(0.88–1.34) | ||||
CC | 81 (21.1%) | 71 (22.5%) | 1.11 (0.71–1.74) | 1.17 (0.76–1.78) | |||||||||
TNS3 | rs3750163 | GG | 325 (84.6%) | 270 (83.8%) | 1.00 | 0.370 | 1.00 | G | 707 (92.1%) | 588 (91.3%) | 1.00 | 0.610 | |
GA | 57 (14.8%) | 48 (14.9%) | 0.93 (0.60–1.44) | 1.01 (0.67–1.54) | 0.580 | A | 61 (7.9%) | 56 (8.7%) | 1.10(0.76–1.61) | ||||
AA | 2 (0.5%) | 4 (1.2%) | 3.25 (0.56–18.93) | 2.41 (0.44–13.24) | |||||||||
TNS3 | rs9876 | GG | 108 (28.1%) | 86 (26.8%) | 1.00 | 0.430 | 1.00 | G | 394 (51.3%) | 337 (52.5%) | 1.00 | 0.660 | |
AG | 178 (46.4%) | 165 (51.4%) | 1.15 (0.79–1.67) | 1.16 (0.82–1.66) | 0.360 | A | 374 (48.7%) | 305 (47.5%) | 0.95(0.77–1.18) | ||||
AA | 98 (25.5%) | 70 (21.8%) | 0.89 (0.57–1.38) | 0.90 (0.59–1.36) | |||||||||