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Table 3 Multivariate predictors for incidence of metachronous cancers after head and neck cancer

From: Impact of age at diagnosis of head and neck cancer on incidence of metachronous cancer

  All cancers Esophageal cancer Lung cancer Other cancers
OR 95%CI P value OR 95%CI P value OR 95%CI P value OR 95%CI P value
Age < 65 years 1.20 0.95–1.52 0.131 1.75 1.27–2.41 < 0.001 0.84 0.50–1.39 0.492 0.89 0.65–1.22 0.465
≥65 years 1    1       1   
Sex Male 1.32 0.94–1.87 0.129 1.20 0.69–1.74 0.697 2.02 0.78–5.22 0.149 1.65 0.99–2.72 0.051
Female 1    1    1    1   
Histological type Squamous cell carcinoma 3.63 1.30–10.1 0.014 7.50 1.02–55.2 0.048     2.17 0.67–7.05 0.196
Others 1    1    Not applicablea 1   
Lesion location Oral cavity 1    1    1    1   
Oropharynx 1.08 0.68–1.72 0.731 1.40 0.72–2.71 0.325 0.33 0.07–1.56 0.162 0.88 0.50–1.57 0.669
Hypopharynx 3.17 2.25–4.48 < 0.001 5.88 3.62–9.55 < 0.001 2.47 1.13–5.42 0.024 1.20 0.76–1.88 0.439
Larynx 1.92 1.34–2.74 < 0.001 1.53 0.88–2.68 0.132 2.14 0.97–4.73 0.061 1.42 0.91–2.20 0.122
  1. OR Odds ratio, CI confidence interval
  2. aHistological type was excluded from the multivariate analysis for metachronous lung cancer which developed only in patients with head and neck squamous cell carcinoma
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