Fig. 3
From: Targeting Ezh2 could overcome docetaxel resistance in prostate cancer cells
Ezh2 was indispensable for the increased population of cancer stem cells in Doc resistant cells. a, b. Inhibition of Ezh2 by DZNEP could reverse Doc-induced gene expression of cancer stem cell markers in LNCaP cells (a) and 22Rv1 cells (b). QPCR was performed after cells were treated with Doc (1 nM) or DNZEP (2 μM) for 2 days. c. Top, representative images showing that inhibition of Ezh2 by DZNEP could reverse Doc-induced enrichment of cancer stem cells in LNCaP and 22Rv1 cells. Bottom, statistical analysis of spheres. Sphere formation assay were conducted after cells were treated with Doc (1 nM) or DNZEP (2 μM) for 2 days