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Table 2 Treatment outcome

From: Oxaliplatin plus leucovorin and 5-fluorouracil (FOLFOX-4) as a salvage chemotherapy in heavily-pretreated platinum-resistant ovarian cancer

 

FOLFOX-4 (n = 29)

Topotecan (n = 26)

Median follow-up, months (range)

45 (1–45)

57 (1–57)

Median PFS, months (95% CI)

2.8 (1.7–4.9)

2.8 (1.8–4.9)

Median OS, months (95% CI)

6.2 (2.4–14.6)

10.4 (4.9–19.5)

Tumor response, n (%)

 CR

1 (3.5)

1 (3.8)

 PR

5 (17.2)

1 (3.8)

 SD

8 (27.6)

6 (23.1)

 PD

15 (51.7)

18 (69.3)

Ca125 response*, n (%)

11 (44.0)

5 (26.3)

Number of patients receiving new treatment after progression, n (%)

16 (57.1)

17 (65.4)

  1. *According to Rustin’s criteria
  2. Abbreviations. CR complete response, FOLFOX-4 oxaliplatin, leucovorin, and 5-fluorouracil, n number, PFS progression-free survival, PD progressive disease, PR partial response, OS overall survival, SD stable disease