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Table 1 Baseline characteristics of the patients treated with chemotherapy

From: Safety and efficacy of cytotoxic chemotherapy in hepatocellular carcinoma after first-line treatment with sorafenib

Baseline characteristics

n=45

Gender, n (%)

 Male

31 (75.6)

 Female

14 (24.4)

Age, median years (min-max)

61.7 (18.9-76.6)

ECOG PS, n(%)

 0-1

41 (91.1)

 2-3

04 (8.9)

Child-Pugh classification, n (%)

 A

33 (73.3)

 B

11 (24.4)

 C

1 (2.2)

BCLC stage, n(%)

 B

11 (24.4)

 C

34 (75.6)

Chronic Liver Disease Etiology, n(%)

 HCV

20 (44.4)

 HBV

9 (20.4)

 Alcohol

8 (18.2)

 NASH

3 (6.9)

 Hemochromatosis

2 (4.5)

 Auto-immune Hepatitis

2 (4.6)

 Cryptogenic

1 (2.3)

Previous treatment, n (%)a

 Resection

7 (15.6)

 RFA

2 (4.4)

 Transplantation

3 (6.7)

 TACE

18 (40)

 None

16 (35.6)

Extrahepatic spread, n(%)

30 (66.7)

Vascular invasion, n(%)

13 (28.9)

CCT regimen (%)

 Doxorubicin

25 (55.6)

 mFLOX/CapOx

9 (20)

 5FU

8 (17.8)

 GemOx

2 (4.4)

 Capecitabine plus IFN

1 (2.2)

Ascites (%)

4 (8.9%)

Alpha fetoprotein, median ng/ml (IQI)

15514.4 (6683.5-24345.5)

Bilirubin median mg/dl (IQI)

1.27 (0.94 – 1.6)

  1. ECOG PS: Eastern Cooperative Oncology Group performance status; BCLC: Barceona Clinic Liver Cancer; HBV: Hepatitis B virus; HCV: Hepatitis C virus; NASH: Non-alcoholic steatohepatitis; RFA: radiofrequency ablation; TACE: transarterial chemoembolization; CCT: cytotoxic chemotherapy; mFLOX: modified 5-fluorouracil and oxaliplatin combination; CapOx: capecitabine and oxaliplatin combination; 5FU: 5-fluorouracil; GemOX: gencitabibe and oxaliplatin combination; IFN: interferon; IQI: interquartile interval. asome patients may have been treated with more than one previous treatment modality.