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Fig. 2 | BMC Cancer

Fig. 2

From: ADSCs and adipocytes are the main producers in the autotaxin–lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro

Fig. 2

Cell type specific differences in ATX production of mammary cells: (a) The expression of ATX on mRNA and protein level by different mammary cells; left: relative ATX mRNA levels compared to HPRT (y-axis) of different cell types (x-axis); right: ATX protein in the conditioned media in ng/ml (y-axis) of different cell types (x-axis); ADSCs have a significantly higher ATX expression than MES on RNA level and a significantly higher expression than epithelial cells on RNA and protein level, MES also have a significantly higher ATX expression than epithelial cells both on RNA and protein level (not plotted for clarity, p < 0.0167, Kruskal–Wallis H test, Mann–Whitney U test with Bonferroni correction); (b) The effect of adipogenic differentiation on the ATX expression; left: relative ATX mRNA expression, right: relative ATX protein expression, x-axis shows the cell type, y-axis shows the ratio of differentiation (Diff) and control (CTL); the biological samples (dots) and the average (line) are plotted; abbreviations: healthy h, tumor-distant td, tumor-adjacent ta, tumor t, EpCAM-positive breast cancer cells BCC, HTB human tumor bank; n = 4 (MCF-10A n = 1, HTB n = 6), *p < 0.05, Kruskal–Wallis H test, Mann–Whitney U test with Bonferroni correction

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