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Table 6 Combination of target therapy and immunotherapy

From: The changing landscape of phase II/III metastatic sarcoma clinical trials—analysis of ClinicalTrials.gov

NCT No.

Drug 1

Drug2

Conditions

Phase

region

Start year

results

NCT03149120

Nivolumab

Pazopanib

Soft Tissue Sarcomas

Phase II

US

2017

No

NCT03190174

Nivolumab

Rapamycin

Undifferentiated Pleomorphic Sarcoma|Liposarcoma|Chondrosarcoma|Osteosarcoma|Ewing Sarcoma

Phase I| Phase II

US

2017

No

NCT02636725

Pembrolizumab

Axitinib

Alveolar Soft Part Sarcoma|Soft Tissue Sarcomas

Phase II

US

2016

No

NCT03359018

Camrelizumab

Apatinib

osteosarcoma

Phase II

Asia

2018

No

NCT03277924

Nivolumab

Sunitinib

Soft Tissue Sarcoma|Bone Sarcoma

Phase I| Phase II

Europe

2017

No

  1. Note: Nivolumab and pembrolizumab are PD-1 antibodies while camrelizumab is PD-L1 antibody