Table 4 Univariate Cox regression analysis of prognostic factors for disease-free survival and overall survival in hepatocellular carcinoma
Variables | Disease-free survival | Overall survival | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
SSBP2 expression (negative vs. positive) | 2.652 (1.355–5.190) | 0.004 | 2.323 (1.101–4.901) | 0.027 |
Tumor size (< 5 cm vs. ≥ 5 cm) | 1.104 (0.723–1.685) | 0.648 | 1.792 (1.237–2.595) | 0.002 |
Focality (single vs. multiple) | 1.553 (0.956–2.523) | 0.075 | 0.904 (0.552–1.481) | 0.689 |
Histologic grade (grade 1&2 vs. 3&4) | 1.763 (1.161–2.676) | 0.008 | 1.744 (1.188–2.562) | 0.005 |
Small vessel invasion | 2.903 (1.932–4.362) | < 0.001 | 2.586 (1.783–3.750) | < 0.001 |
Large vessel invasion | 3.486 (1.944–6.253) | < 0.001 | 3.165 (1.874–5.348) | < 0.001 |
Perineural invasion | 2.067 (0.649–6.585) | 0.219 | 1.920 (0.604–6.105) | 0.269 |
AJCC staging (I & II vs. III & IV) | 3.205 (1.871–5.491) | < 0.001 | 2.528 (1.536–4.162) | < 0.001 |