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Table 4 The gene - gene interaction of XRCC1 and TP53 in the cervical cancer group and the elderly patients above the age of 80 group

From: Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study

 

B

SE

Wald

N

P

OR

95% CI

Recessive model

 Tp53-GG/GC

1.34

0.55

5.85

1

0.02*

3.81

1.29

11.26

 Tp53-GG/GC by XRCC1-GG/GA

−1.07

0.49

4.68

1

0.03*

0.34

0.13

0.90

 常数

−0.13

0.30

0.20

1

0.66

0.88

  

Additive model

 XRCC1

  

5.58

2

0.06

   

 XRCC1-GA

−0.85

0.49

3.03

1

0.08

0.43

0.16

1.11

 XRCC1-AA

0.69

0.74

0.87

1

0.35

1.99

0.47

8.42

 Tp53

  

8.74

2

0.01*

   

 TP53-GC

−1.42

0.48

8.71

1

0.00*

0.24

0.10

0.62

 TP53-CC

−0.81

0.57

2.07

1

0.15

0.44

0.15

1.34

 Tp53 * XRCC1

  

17.22

4

0.00*

   

 TP53-GC by XRCC1-GA

2.87

0.72

16.09

1

0.00*

17.61

4.34

71.50

 TP53-GC by XRCC1-AA

1.22

1.05

1.34

1

0.25

3.37

0.43

26.29

 TP53-CC by XRCC1-GA

0.95

0.81

1.37

1

0.24

2.57

0.53

12.51

 TP53-CC by XRCC1-AA

−0.49

1.19

0.17

1

0.68

0.62

0.06

6.32

 常数

0.61

0.34

3.17

1

0.08

1.85

  

Dominant model

 TP53-GC/CC

−0.96

0.35

7.66

1

0.01*

0.39

0.20

0.76

 TP53-GC/CC by XRCC1-GA/AA

1.29

0.37

12.54

1

0.00*

3.64

1.78

7.43

 常数

0.36

0.22

2.62

1

0.11

1.43

  
  1. *indicated p-value< 0.05