Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study

Table 1 The genotype distribution and H-W of XRCC1 (rs25487), TP53 (rs1042522) and FGFR3 (rs121913483)

Variable	Alleles	Phenotype	N	HWE	MAF	M/M (%)	M/m (%)	m/m (%)	M/M +M/m	M/m +m/m	Allele M	Allele m
rs25487	G > A	Cases	121	0.18	0.40	47(38.9)	51(42.1)	23(19)	98	74	145(59.9)	97(40.1)
		NC	118	0.15	0.25	70(59.3)	38(32.2)	10(8.5)	108	48	178(75.4)	58(24.6)
		OC	101	0.45	0.27	55(54.4)	37(36.6)	9(9)	92	46	147(72.8)	55(27.2)
rs1042522	G > C	Cases	121	0.18	0.38	50(41.3)	50(41.3)	21(17.4)	100	71	150(62)	92(38)
		NC	108	0.74	0.42	37(34.3)	51(47.2)	20(18.5)	88	71	125(57.9)	91(42.1)
		OC	99^a	0.07	0.44	35(35.4)	40(40.4)	24(24.2)	75	64	110(55.6)	88(44.4)
rs121913483	G > C	Cases	117			117	0	0
		NC	113			113	0	0
		OC	89			89	0	0

N Number, HWE Hardy-Weinberg equilibrium, MAF Minor allele frequency, NC Negative controls, OC Old controls
^aThe number of subjects in each group at different sites may be different due to insufficient DNA

ISSN: 1471-2407