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Fig. 4 | BMC Cancer

Fig. 4

From: KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer

Fig. 4

Compounds D14 and C22 decrease the cellular viability of KRas4B-dependent pancreatic cancer cells. a and b Effect of compounds D14 and C22 at various concentrations (0, 6.25, 12.5, 25, 50, 100 and 200 μM) for 72 h on MIA PaCa-2, BxPC-3 and PanC-1 pancreatic cancer cells and on hTERT-HPNE normal pancreatic cells. The results show the viability inhibition of pancreatic cancer cell induced by the treatments. c Morphological visualization of the MIA PaCa-2 and hTERT-HPNE cell lines treated at 200 μM of compounds D14 and C22

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BMC Cancer

ISSN: 1471-2407

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