Liquid biopsy using the supernatant of a pleural effusion for EGFR genotyping in pulmonary adenocarcinoma patients: a comparison between cell-free DNA and extracellular vesicle-derived DNA

Table 2 Concentrations of cfDNA and EV-derived DNA from the supernatant of the pleural effusions

		Supernatant of pleural effusion
		cfDNA concentration (ng/μL)	EV-derived DNA concentration (ng/μL)	P value
EGFR-TKI naïve patients	N = 32	14.7 (10.5–24.3)	22.7 (15.7–36.2)	0.000
EGFR-TKI acquired resistance patients	N = 18	15.4 (11.1–21.8)	18.2 (14.5–32.1)	0.001

Data are expressed as median (IQR), cfDNA cell-free DNA, EV-derived DNA extracellular vesicle-derived DNA

ISSN: 1471-2407