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Table 4 Sensitivity, specificity, PPV and NPV of the different test systems regarding the detection of CIN2+ and CIN3+

From: Performance of a DNA methylation marker panel using liquid-based cervical scrapes to detect cervical cancer and its precancerous stages

  cobas HPV (all 14 types) cobas HPV (HPV16/18) CINtec Plus GynTect
Sensitivity
 CIN2+ 97.3% 66.2% 100.0% 59.7%
 CIN3+ 96.4% 67.3% 100.0% 64.8%
 Cancer 100.0% 80.0% 100.0% 100.0%
Specificity
 CIN2+ 90.2% 95.6% 90.2% 98.0%
 CIN3+ 82.6% 90.6% 69.6% 94.6%
PPV
 CIN2+ 78.3% 84.5% 92.3% 91.5%
 CIN3+ 57.6% 63.8% 69.2% 74.5%
NPV
 CIN2+ 98.9% 88.7% 100.0% 87.3%
 CIN3+ 98.9% 91.9% 100.0% 91.7%
invalid tests 0.36% 0.36% 3.62% 1.43%