Table 4 Sensitivity, specificity, PPV and NPV of the different test systems regarding the detection of CIN2+ and CIN3+
| Â | cobas HPV (all 14 types) | cobas HPV (HPV16/18) | CINtec Plus | GynTect |
|---|---|---|---|---|
Sensitivity | ||||
 CIN2+ | 97.3% | 66.2% | 100.0% | 59.7% |
 CIN3+ | 96.4% | 67.3% | 100.0% | 64.8% |
 Cancer | 100.0% | 80.0% | 100.0% | 100.0% |
Specificity | ||||
 CIN2+ | 90.2% | 95.6% | 90.2% | 98.0% |
 CIN3+ | 82.6% | 90.6% | 69.6% | 94.6% |
PPV | ||||
 CIN2+ | 78.3% | 84.5% | 92.3% | 91.5% |
 CIN3+ | 57.6% | 63.8% | 69.2% | 74.5% |
NPV | ||||
 CIN2+ | 98.9% | 88.7% | 100.0% | 87.3% |
 CIN3+ | 98.9% | 91.9% | 100.0% | 91.7% |
invalid tests | 0.36% | 0.36% | 3.62% | 1.43% |