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Table 4 Association of MMP-9 protein levels with pathology/clinical characteristics of PTC patients

From: The role of matrix metalloproteinase-9 as a prognostic biomarker in papillary thyroid cancer

Variables Mean ± SD Percentiles P value
25th 50th (Median) 75th
Patients
 MNG 218.14 ± 113.74 119.57 226.51 314.39 0.004
 PTC 429.60 ± 288.54 194.88 429.60 467.42
Tissues of PTC patients
 Adjacent non-tumoral 223.15 ± 137.68 107.27 223.15 268.00 < 0.001
 Tumoral 429.60 ± 288.54 194.88 429.60 467.42
Age
 < 45 years 245.01 ± 258.08 90.34 116.59 259.65 0.001
 ≥45 years 570.55 ± 186.12 437.51 570.55 624.80
Sex
 Male 276.52 ± 269.39 71.92 188.94 489.00 0.986
 Female 310.36 ± 361.46 89.21 113.30 471.37
BRAF V600E mutation
 BRAF (−) 256.67 ± 290.37 82.77 100.19 404.35 0.233
 BRAF (+) 345.20 ± 380.80 104.74 179.27 505.23
Tumor size
 < 2 cm 302.53 ± 322.00 77.18 112.10 637.68 0.156
 ≥2 cm 364.04 ± 354.49 156.08 267.42 399.34
TNM Staging
 I/II 220.79 ± 220.09 85.35 116.59 257.37 0.001
 III/IV 673.65 ± 212.97 521.72 673.65 825.58
Focality Status
 Unifocal 193.61 ± 168.46 71.15 107.25 343.48 0.595
 Multifocality 350.86 ± 422.68 82.34 114.49 637.95
Extracapsular invasion
 No 406.12 ± 217.46 243.05 406.12 480.45 0.931
 Yes 500.05 ± 458.36 140.32 500.05 736.08
LNM
 No 269.10 ± 259.47 98.07 209.34 283.47 0.169
 Yes 351.85 ± 254.60 118.68 298.94 637.68
Lymphovascular invasion
 No 196.44 ± 195.59 79.04 108.42 227.12 0.036
 Yes 453.35 ± 345.74 178.74 298.94 805.16
  1. PTC papillary thyroid carcinoma, MNG multinodular goiter, TNM tumor node metastasis, SD standard deviation, LNM lymph node metastasis, P value is for median of MMP-9 expression