Is it sufficient to evaluate bone marrow involvement in newly diagnosed lymphomas using 18F-FDG PET/CT and/or routine iliac crest biopsy? A new approach of PET/CT-guided targeted bone marrow biopsy

Table 1 Clinicopathologic Characteristics of the Study Cohort (n = 299)

Characteristic	No. of patients	%
Study subject	299
Male: Female ratio	1.5
Age, years
median	54.8
range	4–91
PET-assessed skeletal pattern
Focal, isolated	16	5.4
Focal, multiple	67	22.4
Diffuse	52	17.4
Negative	164	54.8
Subtypes of lymphoma
Hodgkin lymphoma^a	25	8.4
Low-grade Non-Hodgkin lymphoma^b	68	22.7
High-grade Non-Hodgkin lymphoma^c	170	56.9
Unclassification^d	17	5.7
Richter transformation	5	1.7
Others	14	4.6

Abbreviations: NLP Nodular lymphocyte predominant, NS Nodular sclerosis lymphomas, MC Mixed cellularity, LR Lymphocyte-rich, DLBC Diffuse large B cell, PTC Peripheral T cell, BL Burkitt lymphoma, ACL Anaplastic large cell, MZ Marginal zone, MC Mantle cell, MALT Mucosa-associated lymphoid tissue, SLL/CLL Chronic lymphocytic leukemia/small lymphocytic lymphoma
^aHodgkin lymphoma included 3 NLP, 10 NS, 8 MC, 4 LR
^bLow-grade Non-Hodgkin lymphoma included 24 Follicular,10 MZ, 13 MC, 9 MALT, 12 SLL/CLL
^cHigh-grade Non-Hodgkin lymphoma included 129 DLBC, 8 PTC, 2 BL, 5 ACL, 2 Lymphoblastic, 25 NK-T
^dUnclassification included 8 B-cell lymphomas, 8 T-cell lymphomas

ISSN: 1471-2407