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Table 1 The concentration of flavonoids necessary for 50% inhibition (IC50 values). Data of mean ± SEM are from four analytical experiments, each conducted in triplicate. bFR: fold-drug resistance was derived by dividing the IC50 concentration for doxorubicin of KB 3–1 and KBCHR8–5 cells in the absence/presence of flavonoids by IC50 value for doxorubicin of KB 3–1 cells

From: Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines

Compound KB 3–1 KB ChR 8–5
IC50 ± SEMα (μM) FRb IC50 ± SEMα (μΜ) FRb
Doxorubicin 0.04 ± 0.01 [1.0] 7 ± 0.20 [175.0]
+ 1 μM Theaflavine 0.03 ± 0.01 [0.8] 3 ± 0.04 [75.0]
+ 5 μM Theaflavine 0.02 ± 0.01 [0.5] 0.6 ± 0. 03 [15.0]
+ 10 μM Theaflavine 0.02 ± 0.01 [0.5] 0.3 ± 0.02 [7.5]
+ 1 μM Quercetin 0.02 ± 0.01 [0.5] 4 ± 0.05 [100.0]
+ 5 μM Quercetin 0.03 ± 0.01 [0.8] 1 ± 0.01 [25.0]
+ 10 μM Quercetin 0.02 ± 0.01 [0.5] 0.6 ± 0.01 [15.0]
+ 1 μM Rutin 0.03 ± 0.01 [0.8] 6 ± 0.05 [150.0]
+ 5 μM Rutin 0.02 ± 0.01 [0.5] 3 ± 0.01 [75.0]
+ 10 μM Rutin 0.02 ± 0.01 [0.5] 0.7 ± 0.01 [17.5]
+ 1 μM E3G 0.02 ± 0.01 [0.5] 5 ± 0.04 [125.0]
+ 5 μM E3G 0.03 ± 0.01 [0.8] 3 ± 0.02 [75.0]
+ 10 μM E3G 0.02 ± 0.01 [0.5] 1 ± 0.02 [25.0]
+ 1 μM Tamarixetin 0.03 ± 0.01 [0.8] 6 ± 0.03 [150.0]
+ 5 μM Tamarixetin 0.02 ± 0.01 [0.5] 4 ± 0.02 [100.0]
+ 10 μM Tamarixetin 0.02 ± 0.01 [0.5] 2 ± 0.01 [50.0]