Fig. 1

Effects of acyclic retinoid (ACR) and angiotensin-II receptor blocker (ARB) on hepatocarcinogenesis in diabetic rats. a Schematic of diethylnitrosamine (DEN)-induced rat hepatocarcinogenesis models. b The values of Quantitative Insulin Sensitivity Check Index (QUICKI) (Upper panel) and Homeostasis model assessment-Insulin Resistance (HOMA-IR) (Lower panel) in experimental rats. c Representative microphotographs of hematoxylin and eosin (H&E) staining (Left panels) and glutathione S-transferase (GST-P)-positive preneoplastic foci (Right panels). d Number of GST-P positive neoplastic lesions (GST-P⁺ PNL) per square centimeter (Upper panel) and relative size of GST-P⁺ PNL (Lower panel). LETO; Long-Evans Tokushima Otsuka rat, OLETF; Otsuka Long-Evans Tokushima Fatty rat. Data are mean ± SD (n = 10). *, P ≤ 0.01 as compared with the values of LETO (b); *, P ≤ 0.01 between each group (d)