Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin

BMC Cancer

Table 3 Association between immunohistochemical markers and percent density ^a

Marker	No staining		Weak staining		Strong staining		p _trend ^b
Marker	Mean	95% CI	Mean	95% CI	Mean	95% CI
COX2: normal	35.6	29.6, 41.5	35.8	29.3, 42.2	32.8	27.6, 38.0	0.43
COX2: tumor	30.5	23.9, 37.1	33.1	26.1, 40.1	35.2	30.2, 40.2	0.22
TGF-β: tumor	36.2	28.6, 43.7	32.4	27.8, 37.0	34.7	29.5, 40.0	0.95
TNF-α: tumor	30.5	24.4, 36.6	34.2	29.6, 38.7	32.9	26.3, 39.4	0.54
Vimentin: normal	32.9	27.1, 38.7	33.9	30.1, 37.7	31.6	24.5, 38.6	0.83
Vimentin: tumor	35.4	29.2, 41.6	35.0	30.2, 39.7	32.9	28.9, 36.8	0.40
IGF-1R: tumor	32.6	27.1, 38.0	37.7	32.1, 43.2	30.4	25.4, 35.4	0.51
IGFBP-2: tumor	36.7	30.5, 42.9	31.7	26.1, 37.4	33.8	28.4, 39.2	0.52

^aAdjusted means were obtained from linear regression adjusted for age and BMI
^bp_trend obtained from linear regression using staining (0–2) as continuous variable

ISSN: 1471-2407