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Table 2 Number of Clinically Relevant Interactions Stratified by Medication Characteristics

From: Prevalence of drug-drug interactions in oncology patients enrolled on National Clinical Trials Network oncology clinical trials

Medication Characteristic Total patients on protocol with characteristic Clinically relevanta interactions with characteristic (%)
CYP450 metabolism 98 7 (7.1%)
P-glycoprotein transport 69 2 (2.9%)
QT prolongation 23 2 (8.7%)
pH dependent absorption 6 1 (16.7%)
  1. aClinical relevance was determined by study team review and defined as a drug-drug interaction that would require a medication change to ensure study medication safety/efficacy at enrollment