Prevalence of drug-drug interactions in oncology patients enrolled on National Clinical Trials Network oncology clinical trials

Table 2 Number of Clinically Relevant Interactions Stratified by Medication Characteristics

Medication Characteristic	Total patients on protocol with characteristic	Clinically relevant^a interactions with characteristic (%)
CYP450 metabolism	98	7 (7.1%)
P-glycoprotein transport	69	2 (2.9%)
QT prolongation	23	2 (8.7%)
pH dependent absorption	6	1 (16.7%)

^aClinical relevance was determined by study team review and defined as a drug-drug interaction that would require a medication change to ensure study medication safety/efficacy at enrollment

ISSN: 1471-2407