Table 1 Baseline patient, tumor and prior surgery treatment characteristics according to actually received study group (ALND vs SLNB)
Test | Class | All (n = 963) | ALND (n = 443) | SLNB alone (n = 520) | p-value |
|---|---|---|---|---|---|
Age | Median [range] | 58 [26–84] | 59 [33–84] | 58 [26–84] | 0.761 |
<= 40 | 51 (5.30) | 26 (5.87) | 25 (4.81) | 0.7142 | |
41–75 | 858 (89.10) | 391 (88.26) | 467 (89.81) | ||
> 75 | 54 (5.61) | 26 (5.87) | 28 (5.38) | ||
Clinical T stage | T1 | 571(59.60) | 261(59.32) | 310(59.85) | 0.9393 |
T2 | 342 (35.70) | 156 (35.45) | 186 (35.91) | ||
T3 | 17 (1.77) | 9 (2.05) | 8 (1.54) | ||
T4 | 5 (0.52) | 2 (0.45) | 3 (0.58) | ||
Tis/Tx | 23 (2.40) | 12 (2.73) | 11 (2.12) | ||
Tumor size (mm) | Median [range] | 18 [0–81] | 18 [0–80] | 18 [0–81] | 0.573 |
<=10 | 151 (15.83) | 64 (14.61) | 87 (16.86) | 0.5097 | |
10–30 | 704 (73.79) | 331 (75.57) | 373 (72.29) | ||
> 30 | 99 (10.38) | 43 (9.82) | 56 (10.85) | ||
Histology Type | Infiltrating ductal | 781(81.10) | 358(80.81) | 423(81.35) | 0.8805 |
Infiltrating lobular | 102 (10.59) | 45 (10.16) | 57 (10.96) | ||
Mixed | 26 (2.70) | 13 (2.93) | 13 (2.50) | ||
Other | 54 (5.61) | 27 (6.09) | 27 (5.19) | ||
SBR Grade | Gr I | 213 (22.76) | 101 (23.60) | 112 (22.05) | 0.2677 |
Gr II | 479 (51.18) | 207 (48.36) | 272 (53.54) | ||
Gr III | 244 (26.07) | 120 (28.04) | 124 (24.41) | ||
LVI | No | 281 (30.38) | 134 (31.60) | 147 (29.34) | 0.4560 |
Yes | 644 (69.62) | 290 (68.40) | 354 (70.66) | ||
Capsular Effraction | No | 698 (80.14) | 327 (80.74) | 371 (79.61) | 0.6775 |
Yes | 173 (19.86) | 78 (19.26) | 95 (20.39) | ||
Hormonal receptors status | Negative | 84 (8.89) | 44 (10.16) | 40 (7.81) | 0.2061 |
Positive | 861 (91.11) | 389 (89.84) | 472 (92.19) | ||
HER2 status | Negative | 815 (87.73) | 369 (86.42) | 446 (88.84) | 0.26106 |
Positive | 114 (12.27) | 58 (13.58) | 56 (11.16) | ||
Tumor subtype (RH/HER2) | RH+/HER2+ | 83 (9.00) | 41 (9.72) | 42 (8.40) | 0.5150 |
RH+/HER2- | 759 (82.32) | 339 (80.33) | 420 (84.00) | ||
RH-/HER2+ | 30 (3.25) | 16 (3.79) | 14 (2.80) | ||
RH-/HER2- | 50 (5.42) | 26 (6.16) | 24 (4.80) | ||
Harvested SN, number | Median [range] | 2[0–8] | 2[0–7] | 2[1–8] | 0.996 |
0 | 2 (0.21) | 2 (0.45) | 0.2823 | ||
1 | 373 (38.73) | 168 (37.92) | 205 (39.42) | ||
> 2 | 588 (61.06) | 273 (61.63) | 315 (60.58) | ||
Median [range] | 1[0–4] | 1[0–4] | 1[0–3] | 0.422 | |
Involved SN | <=2 | 925 (98.51) | 424 (98.60) | 501 (98.43) | 0.8242 |
> 2 | 14 (1.49) | 6 (1.40) | 8 (1.57) | ||
ITC | 57 (6.31) | 22 (5.30) | 35 (7.17) | 0.5040 | |
SN status | Micro | 298 (33.00) | 137 (33.01) | 161 (32.99) | |
Macro | 548 (60.69) | 256 (61.69) | 292 (59.84) |