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Table 4 Univariate and Multivariate analysis among factors which might affect the recurrence and the disease free survival (DFS)

From: Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients

  Recurrence DFS
Univariate Analysis Multivariate Analysis Univariate Analysis Multivariate Analysis
HR 95% CI p value HR 95% CI p value HR 95% CI p value HR 95% CI p value
NLR
  ≤ 4.7 1    1    1    1   
  > 4.7 1.67 0.64–4.36 0.293 1.1 0.38–3.21 0.862 2.03 1.16–3.57 0.014 1.88 1.01–3.52 0.048
Gender
 Female 1    1    1    1   
 Male 1.81 0.81–4.04 0.15 1.73 0.76–3.93 0.189 1.36 0.84–2.18 0.207 1.41 0.87–2.30 0.163
Age
  ≤ 72 1    1    1    1   
  > 72 0.9 0.44–1.83 0.763 1.02 0.48–2.17 0.949 1.70 1.08–2.65 0.021 1.83 1.15–2.91 0.011
Primary tumor
 Right colon 1    1    1    1   
 Left colon 0.84 0.29–2.46 0.753 0.7 0.23–2.14 0.535 0.81 0.41–1.61 0.543 0.71 0.35–1.46 0.354
 Rectum 1.34 0.61–2.96 0.463 1.53 0.66–3.55 0.316 1.39 0.85–2.28 0.196 1.46 0.85–2.51 0.175
Grade
 Low 1    1    1    1   
 Medium + High 1.43 0.55–3.73 0.464 1.98 0.73–5.35 0.177 1.14 0.65–2.00 0.646 1.18 0.66–2.14 0.574
T
 T1 1       1      
 T2 8.74E + 08 8.74e + 08–8.74e + 08 .     2.96 0.38–22.96 0.299    
 T3 1.68e + 09 5.79e + 08–4.88e + 09 0     5.2 0.72–37.60 0.102    
 T4 3.33e + 09 8.89e + 08–1.25e + 10 0     8.95 1.16–69.40 0.036    
N
 N0 1       1      
 N1 1.06 0.43–2.57 0.906     1.04 0.61–1.79 0.884    
 N2 3.60 1.54–8.46 0.003     2.88 1.64–5.07 < 0.001    
No lymph nodes yield
  ≥ 12 1       1    1   
  < 12 0.55 0.13–2.29 0.408 0.55 0.13–2.44 0.433 1.56 0.86–2.83 0.145 1.7 0.89–3.24 0.106
Stage
 Stage I 1       1    1   
 Stage II 3.86 0.88–16.99 0.074 5.14 1.14–23.30 0.034 2.35 1.09–5.07 0.029 2.80 1.28–6.10 0.01
 Stage III 4.81 1.10–21.05 0.037 5.22 1.13–24.13 0.035 2.80 1.30–6.03 0.008 3.06 1.38–6.78 0.006
Perineural invasion
 No 1       1    1   
 Yes 2.03 0.71–5.84 0.189 0.89 0.26–3.05 0.848 1.37 0.63–2.99 0.428 0.54 0.22–1.32 0.176
Vascular invasion
 No 1    1    1    1   
 Yes 4.05 1.93–8.49 0 4.23 1.78–10.03 0.001 2.36 1.39–4.02 0.001 2.38 1.26–4.49 0.007
Lymphatic invasion
 No 1    1    1    1   
 Yes 2.42 1.04–5.64 0.04 1.16 0.43–3.11 0.769 2.07 1.20–3.59 0.009 1.48 0.77–2.83 0.237
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