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Table 4 Univariate and Multivariate analysis among factors which might affect the recurrence and the disease free survival (DFS)

From: Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients

 

Recurrence

DFS

Univariate Analysis

Multivariate Analysis

Univariate Analysis

Multivariate Analysis

HR

95% CI

p value

HR

95% CI

p value

HR

95% CI

p value

HR

95% CI

p value

NLR

  ≤ 4.7

1

  

1

  

1

  

1

  

  > 4.7

1.67

0.64–4.36

0.293

1.1

0.38–3.21

0.862

2.03

1.16–3.57

0.014

1.88

1.01–3.52

0.048

Gender

 Female

1

  

1

  

1

  

1

  

 Male

1.81

0.81–4.04

0.15

1.73

0.76–3.93

0.189

1.36

0.84–2.18

0.207

1.41

0.87–2.30

0.163

Age

  ≤ 72

1

  

1

  

1

  

1

  

  > 72

0.9

0.44–1.83

0.763

1.02

0.48–2.17

0.949

1.70

1.08–2.65

0.021

1.83

1.15–2.91

0.011

Primary tumor

 Right colon

1

  

1

  

1

  

1

  

 Left colon

0.84

0.29–2.46

0.753

0.7

0.23–2.14

0.535

0.81

0.41–1.61

0.543

0.71

0.35–1.46

0.354

 Rectum

1.34

0.61–2.96

0.463

1.53

0.66–3.55

0.316

1.39

0.85–2.28

0.196

1.46

0.85–2.51

0.175

Grade

 Low

1

  

1

  

1

  

1

  

 Medium + High

1.43

0.55–3.73

0.464

1.98

0.73–5.35

0.177

1.14

0.65–2.00

0.646

1.18

0.66–2.14

0.574

T

 T1

1

     

1

     

 T2

8.74E + 08

8.74e + 08–8.74e + 08

.

   

2.96

0.38–22.96

0.299

   

 T3

1.68e + 09

5.79e + 08–4.88e + 09

0

   

5.2

0.72–37.60

0.102

   

 T4

3.33e + 09

8.89e + 08–1.25e + 10

0

   

8.95

1.16–69.40

0.036

   

N

 N0

1

     

1

     

 N1

1.06

0.43–2.57

0.906

   

1.04

0.61–1.79

0.884

   

 N2

3.60

1.54–8.46

0.003

   

2.88

1.64–5.07

< 0.001

   

No lymph nodes yield

  ≥ 12

1

     

1

  

1

  

  < 12

0.55

0.13–2.29

0.408

0.55

0.13–2.44

0.433

1.56

0.86–2.83

0.145

1.7

0.89–3.24

0.106

Stage

 Stage I

1

     

1

  

1

  

 Stage II

3.86

0.88–16.99

0.074

5.14

1.14–23.30

0.034

2.35

1.09–5.07

0.029

2.80

1.28–6.10

0.01

 Stage III

4.81

1.10–21.05

0.037

5.22

1.13–24.13

0.035

2.80

1.30–6.03

0.008

3.06

1.38–6.78

0.006

Perineural invasion

 No

1

     

1

  

1

  

 Yes

2.03

0.71–5.84

0.189

0.89

0.26–3.05

0.848

1.37

0.63–2.99

0.428

0.54

0.22–1.32

0.176

Vascular invasion

 No

1

  

1

  

1

  

1

  

 Yes

4.05

1.93–8.49

0

4.23

1.78–10.03

0.001

2.36

1.39–4.02

0.001

2.38

1.26–4.49

0.007

Lymphatic invasion

 No

1

  

1

  

1

  

1

  

 Yes

2.42

1.04–5.64

0.04

1.16

0.43–3.11

0.769

2.07

1.20–3.59

0.009

1.48

0.77–2.83

0.237

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