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Table 4 The relationship between CTCs number with different karyotypes and TNM stage of NPC patients

From: Circulating tumor cells with karyotyping as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma

Stagea Newly diagnosis (M0, N = 29) Relapse/Distant metastasis after treatment (N = 21)
Mean number of CTCs Mean number of CTCs
Triploid Tetraploid Multiploidb Diploidc Triploid Tetraploid Multiploid
Total 1.6 0.5 1.1 1.2 2.1 1.6 3.7
T-classification
 T1 1.5 0.25 0.5 0 1.0 1.5 0
 T2 1.2 0.6 2.0 0 1.7 0.3 1.3
 T3 1.3 0.7 1.0 0 3.0 2.0 2.5
 T4 2.1 1.1 1.6 2.6 2.0 1.7 5.8
N-classification
 N0 1.7 1.0 0.3 0 8.0 7.0 1.0
 N1 1.0 0 0 3.7 2.6 2.7 7.4
 N2 1.7 0.8 1.9 0 1.7 0.2 0.7
 N3 1.4 0.6 0 0 1.0 1.3 4.5
TNM stage
 II 0.5 0 0 0 1.0 1.5 0
 III 1.5 0.6 1.6 0 2.7 1.1 0.7
 IV 1.9 1.0 1.3 2.2 2.0 1.8 6.0
  1. a Stage for patients with relapse/distant metastasis after treatment refered to TNM stage at NPC initial diagnosis
  2. b Multiploid of chromosome 8 contained pentaploidy and those > 5 copies
  3. c Only one patient with distant metastasis was detected EpCAM (+) diploid CTCs