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Table 3 Univariate and multivariate cox hazards analysis for Disease-free survival in 539 patients with HCC

From: A novel score based on serum apolipoprotein A-1 and C-reactive protein is a prognostic biomarker in hepatocellular carcinoma patients

Variables

Univariate analysis

Multivariate analysis

Χ 2

p-Value

HR

95%CI

p-Value

Gender

 Male vs. Female

0.030

0.861

   

Age (years)

  < 53 vs. ≥ 53

0.423

0.515

   

TNM stage

 III-IV vs. I-II

121.676

< 0.001

3.068

2.263–4.160

< 0.001

Tumor size(cm)

  < 5 vs. ≥ 5

121.603

< 0.001

   

Tumor number

 Single vs. Multiple

20.408

< 0.001

   

Node stage

 N0 vs. N1–2

15.031

< 0.001

   

Distant metastases

 Yes vs. No

7.069

0.008

   

BMI (kg/m2)

  ≥ 24.0 vs. 18.5–23.9 vs. < 18.5

4.431

0.109

   

Alcohol behavior

 Previous/Current vs. Current

0.178

0.915

   

Family history of cancer

 Yes vs. No

3.929

0.140

   

HBs Ag

 Positive vs. Negative

0.778

0.378

   

HBe Ag

 Positive vs. Negative

1.937

0.164

   

AFP (ng/mL)

  < 400 vs. ≥400

28.609

< 0.001

1.710

1.292–2.264

< 0.001

TC(mmol/L)

  < 5.69 vs. ≥5.69

0.182

0.670

   

TG(mmol/L)

  < 1.7 vs. ≥1.7

0.626

0.429

   

HDL(mmol/L)

  < 1.16 vs. ≥1.16

5.056

0.025

   

LDL(mmol/L)

  < 3.1 vs. ≥3.1

0.292

0.589

   

ApoA1(g/L)

  < 1.20 vs. ≥1.20

30.090

< 0.001

0.588

0.440–0.786

< 0.001

ApoB(g/L)

  < 1.10 vs. ≥1.10

0.675

0.411

   

CRP(mg/L)

  < 3.0 vs. ≥ 3.0

64.842

< 0.001

2.056

1.491–2.834

< 0.001

  1. Abbreviations:HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, AFP alpha fetoprotein, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA-1 apolipoprotein A-1, ApoB apolipoprotein B; CRP C-reactive protein
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BMC Cancer

ISSN: 1471-2407

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