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Table 3 Univariate and multivariate cox hazards analysis for Disease-free survival in 539 patients with HCC

From: A novel score based on serum apolipoprotein A-1 and C-reactive protein is a prognostic biomarker in hepatocellular carcinoma patients

Variables Univariate analysis Multivariate analysis
Χ 2 p-Value HR 95%CI p-Value
Gender
 Male vs. Female 0.030 0.861    
Age (years)
  < 53 vs. ≥ 53 0.423 0.515    
TNM stage
 III-IV vs. I-II 121.676 < 0.001 3.068 2.263–4.160 < 0.001
Tumor size(cm)
  < 5 vs. ≥ 5 121.603 < 0.001    
Tumor number
 Single vs. Multiple 20.408 < 0.001    
Node stage
 N0 vs. N1–2 15.031 < 0.001    
Distant metastases
 Yes vs. No 7.069 0.008    
BMI (kg/m2)
  ≥ 24.0 vs. 18.5–23.9 vs. < 18.5 4.431 0.109    
Alcohol behavior
 Previous/Current vs. Current 0.178 0.915    
Family history of cancer
 Yes vs. No 3.929 0.140    
HBs Ag
 Positive vs. Negative 0.778 0.378    
HBe Ag
 Positive vs. Negative 1.937 0.164    
AFP (ng/mL)
  < 400 vs. ≥400 28.609 < 0.001 1.710 1.292–2.264 < 0.001
TC(mmol/L)
  < 5.69 vs. ≥5.69 0.182 0.670    
TG(mmol/L)
  < 1.7 vs. ≥1.7 0.626 0.429    
HDL(mmol/L)
  < 1.16 vs. ≥1.16 5.056 0.025    
LDL(mmol/L)
  < 3.1 vs. ≥3.1 0.292 0.589    
ApoA1(g/L)
  < 1.20 vs. ≥1.20 30.090 < 0.001 0.588 0.440–0.786 < 0.001
ApoB(g/L)
  < 1.10 vs. ≥1.10 0.675 0.411    
CRP(mg/L)
  < 3.0 vs. ≥ 3.0 64.842 < 0.001 2.056 1.491–2.834 < 0.001
  1. Abbreviations:HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, AFP alpha fetoprotein, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA-1 apolipoprotein A-1, ApoB apolipoprotein B; CRP C-reactive protein