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Table 2 Univariate and multivariate cox hazards analysis for overall survival in 539 patients with HCC

From: A novel score based on serum apolipoprotein A-1 and C-reactive protein is a prognostic biomarker in hepatocellular carcinoma patients

Variables

Univariate analysis

Multivariate analysis

Χ 2

p-Value

HR

95%CI

p-Value

Gender

 Male vs. Female

0.035

0.853

   

Age (years)

  < 53 vs. ≥ 53

0.481

0.488

   

TNM stage

 III-IV vs. I-II

122.544

< 0.001

3.068

2.263–4.160

< 0.001

Tumor size(cm)

  < 5 vs. ≥ 5

122.424

< 0.001

   

Tumor number

 Single vs. Multiple

20.516

< 0.001

   

Node stage

 N0 vs. N1–2

15.215

< 0.001

   

Distant metastases

 Yes vs. No

7.140

0.008

   

BMI (kg/m2)

  ≥ 24.0 vs. 18.5–23.9 vs. < 18.5

4.454

0.108

   

Alcohol behavior

 Previous/Current vs. Current

0.193

0.908

   

Family history of cancer

 Yes vs. No

3.851

0.146

   

HBs Ag

 Positive vs. Negative

0.749

0.384

   

HBe Ag

 Positive vs. Negative

2.015

0.156

   

AFP (ng/mL)

  < 400 vs. ≥400

27.697

< 0.001

1.710

1.292–2.264

< 0.001

TC(mmol/L)

  < 4.625 vs. ≥4.625

0.241

0.624

   

TG(mmol/L)

  < 0.615 vs. ≥0.615

0.154

0.695

   

HDL(mmol/L)

  < 1.085 vs. ≥1.085

6.534

0.011

   

LDL(mmol/L)

  < 2.695 vs. ≥2.695

20.524

0.469

   

ApoA-1(g/L)

  < 1.075 vs. ≥1.075

34.756

< 0.001

0.588

0.440–0.786

< 0.001

ApoB(g/L)

  < 0.635 vs. ≥0.635

0.854

0.356

   

CRP(mg/L)

  < 6.805 vs. ≥ 6.805

73.715

< 0.001

2.056

1.491–2.834

< 0.001

  1. Abbreviations: HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, AFP alpha fetoprotein, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA-1 apolipoprotein A-1, ApoB apolipoprotein B, CRP C-reactive protein
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BMC Cancer

ISSN: 1471-2407

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