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Table 2 Univariate and multivariate cox hazards analysis for overall survival in 539 patients with HCC

From: A novel score based on serum apolipoprotein A-1 and C-reactive protein is a prognostic biomarker in hepatocellular carcinoma patients

Variables Univariate analysis Multivariate analysis
Χ 2 p-Value HR 95%CI p-Value
Gender
 Male vs. Female 0.035 0.853    
Age (years)
  < 53 vs. ≥ 53 0.481 0.488    
TNM stage
 III-IV vs. I-II 122.544 < 0.001 3.068 2.263–4.160 < 0.001
Tumor size(cm)
  < 5 vs. ≥ 5 122.424 < 0.001    
Tumor number
 Single vs. Multiple 20.516 < 0.001    
Node stage
 N0 vs. N1–2 15.215 < 0.001    
Distant metastases
 Yes vs. No 7.140 0.008    
BMI (kg/m2)
  ≥ 24.0 vs. 18.5–23.9 vs. < 18.5 4.454 0.108    
Alcohol behavior
 Previous/Current vs. Current 0.193 0.908    
Family history of cancer
 Yes vs. No 3.851 0.146    
HBs Ag
 Positive vs. Negative 0.749 0.384    
HBe Ag
 Positive vs. Negative 2.015 0.156    
AFP (ng/mL)
  < 400 vs. ≥400 27.697 < 0.001 1.710 1.292–2.264 < 0.001
TC(mmol/L)
  < 4.625 vs. ≥4.625 0.241 0.624    
TG(mmol/L)
  < 0.615 vs. ≥0.615 0.154 0.695    
HDL(mmol/L)
  < 1.085 vs. ≥1.085 6.534 0.011    
LDL(mmol/L)
  < 2.695 vs. ≥2.695 20.524 0.469    
ApoA-1(g/L)
  < 1.075 vs. ≥1.075 34.756 < 0.001 0.588 0.440–0.786 < 0.001
ApoB(g/L)
  < 0.635 vs. ≥0.635 0.854 0.356    
CRP(mg/L)
  < 6.805 vs. ≥ 6.805 73.715 < 0.001 2.056 1.491–2.834 < 0.001
  1. Abbreviations: HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, AFP alpha fetoprotein, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA-1 apolipoprotein A-1, ApoB apolipoprotein B, CRP C-reactive protein