Table 4 Meta-analysis of the association of null genotypes of GSTM1, GSTT1 and dual-null genotype of GSTM1/GSTT1 with bladder carcinogens risk
From: Association of Glutathione S-transferase gene polymorphism with bladder Cancer susceptibility
Genetic contrasts | Group and subgroups | Studies Number | Q test P value | Model selected | OR (95% CI) | P |
|---|---|---|---|---|---|---|
GSTM1 | ||||||
 - vs + | Overall | 72 | <0.00001 | Random | 1.40 (1.31,1.48) | <0.00001 |
Caucasian | 37 | <0.00001 | Random | 1.39 (1.26,1.54) | <0.00001 | |
Asian | 20 | 0.39 | Fixed | 1.45 (1.33,1.59) | <0.00001 | |
African | 9 | 0.10 | Random | 1.54 (1.16,2.05) | 0.003 | |
Hospital-based | 46 | 0.0001 | Random | 1.42 (1.32,1.52) | <0.00001 | |
Population-based | 26 | 0.003 | Random | 1.36 (1.21,1.53) | <0.00001 | |
High quality | 54 | 0.0002 | Random | 1.37 (1.28,1.45) | <0.00001 | |
Low quality | 18 | 0.0009 | Random | 1.58 (1.29,1.94) | <0.0001 | |
GSTM1 (smoking) | ||||||
 - vs + | Overall | 24 | 0.02 | Random | 1.37 (1.19,1.59) | <0.0001 |
Caucasian | 10 | 0.007 | Random | 1.17 (0.85,1.59) | 0.33 | |
Asian | 7 | 0.63 | Fixed | 1.67 (1.32,2.11) | <0.0001 | |
African | 3 | 0.22 | Fixed | 1.44 (0.95,2.17) | 0.08 | |
High quality | 17 | 0.02 | Random | 1.35 (1.14,1.60) | 0.0005 | |
Low quality | 7 | 0.27 | Fixed | 1.48 (1.12,1.96) | 0.006 | |
GSTT1 | ||||||
 - vs + | Overall | 61 | <0.00001 | Random | 1.11 (1.01,1.22) | 0.03 |
Caucasian | 29 | <0.00001 | Random | 1.16 (0.99,1.36) | 0.07 | |
Asian | 21 | 0.01 | Random | 1.05 (0.91,1.22) | 0.51 | |
African | 4 | 0.03 | Random | 1.07 (0.65,1.76) | 0.79 | |
Hospital-based | 40 | <0.0001 | Random | 1.11 (0.99,1.24) | 0.07 | |
Population-based | 21 | 0.0002 | Random | 1.12 (0.94,1.35) | 0.20 | |
High quality | 52 | <0.00001 | Random | 1.14 (1.03,1.26) | 0.01 | |
Low quality | 9 | 0.23 | Fixed | 0.93 (0.75,1.14) | 0.49 | |
GSTT1 (smoking) | ||||||
| Â | Overall | 21 | 0.67 | Fixed | 1.06 (0.93,1.20) | 0.38 |
Caucasian | 9 | 0.84 | Fixed | 1.14 (0.91,1.43) | 0.24 | |
Asian | 7 | 0.62 | Fixed | 1.00 (0.77,1.30) | 0.99 | |
African | 2 | 0.41 | Fixed | 0.60 (0.36,1.02) | 0.06 | |
High quality | 16 | 0.52 | Fixed | 1.06 (0.93,1.22) | 0.37 | |
Low quality | 5 | 0.64 | Fixed | 1.01 (0.70,1.48) | 0.94 | |
Dual-null genotype of GSTM1/GSTT1 | ||||||
| Â | Overall | 18 | 0.003 | Random | 1.48 (1.15,1.92) | 0.002 |
Caucasian | 8 | 0.03 | Random | 1.30 (0.83,2.03) | 0.25 | |
Asian | 7 | 0.04 | Random | 1.62 (1.15,2.28) | 0.006 | |
Hospital-based | 13 | 0.03 | Random | 1.71 (1.28,2.28) | 0.0003 | |
Population-based | 5 | 0.06 | Random | 1.07 (0.67,1.71) | 0.77 | |
High quality | 15 | 0.11 | Fixed | 1.61 (1.36,1.91) | <0.00001 | |
Low quality | 3 | 0.04 | Random | 0.86 (0.40,1.85) | 0.70 | |