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Table 4 Meta-analysis of the association of null genotypes of GSTM1, GSTT1 and dual-null genotype of GSTM1/GSTT1 with bladder carcinogens risk

From: Association of Glutathione S-transferase gene polymorphism with bladder Cancer susceptibility

Genetic contrasts Group and subgroups Studies Number Q test P value Model selected OR (95% CI) P
GSTM1
 - vs + Overall 72 <0.00001 Random 1.40 (1.31,1.48) <0.00001
Caucasian 37 <0.00001 Random 1.39 (1.26,1.54) <0.00001
Asian 20 0.39 Fixed 1.45 (1.33,1.59) <0.00001
African 9 0.10 Random 1.54 (1.16,2.05) 0.003
Hospital-based 46 0.0001 Random 1.42 (1.32,1.52) <0.00001
Population-based 26 0.003 Random 1.36 (1.21,1.53) <0.00001
High quality 54 0.0002 Random 1.37 (1.28,1.45) <0.00001
Low quality 18 0.0009 Random 1.58 (1.29,1.94) <0.0001
GSTM1 (smoking)
 - vs + Overall 24 0.02 Random 1.37 (1.19,1.59) <0.0001
Caucasian 10 0.007 Random 1.17 (0.85,1.59) 0.33
Asian 7 0.63 Fixed 1.67 (1.32,2.11) <0.0001
African 3 0.22 Fixed 1.44 (0.95,2.17) 0.08
High quality 17 0.02 Random 1.35 (1.14,1.60) 0.0005
Low quality 7 0.27 Fixed 1.48 (1.12,1.96) 0.006
GSTT1
 - vs + Overall 61 <0.00001 Random 1.11 (1.01,1.22) 0.03
Caucasian 29 <0.00001 Random 1.16 (0.99,1.36) 0.07
Asian 21 0.01 Random 1.05 (0.91,1.22) 0.51
African 4 0.03 Random 1.07 (0.65,1.76) 0.79
Hospital-based 40 <0.0001 Random 1.11 (0.99,1.24) 0.07
Population-based 21 0.0002 Random 1.12 (0.94,1.35) 0.20
High quality 52 <0.00001 Random 1.14 (1.03,1.26) 0.01
Low quality 9 0.23 Fixed 0.93 (0.75,1.14) 0.49
GSTT1 (smoking)
  Overall 21 0.67 Fixed 1.06 (0.93,1.20) 0.38
Caucasian 9 0.84 Fixed 1.14 (0.91,1.43) 0.24
Asian 7 0.62 Fixed 1.00 (0.77,1.30) 0.99
African 2 0.41 Fixed 0.60 (0.36,1.02) 0.06
High quality 16 0.52 Fixed 1.06 (0.93,1.22) 0.37
Low quality 5 0.64 Fixed 1.01 (0.70,1.48) 0.94
Dual-null genotype of GSTM1/GSTT1
  Overall 18 0.003 Random 1.48 (1.15,1.92) 0.002
Caucasian 8 0.03 Random 1.30 (0.83,2.03) 0.25
Asian 7 0.04 Random 1.62 (1.15,2.28) 0.006
Hospital-based 13 0.03 Random 1.71 (1.28,2.28) 0.0003
Population-based 5 0.06 Random 1.07 (0.67,1.71) 0.77
High quality 15 0.11 Fixed 1.61 (1.36,1.91) <0.00001
Low quality 3 0.04 Random 0.86 (0.40,1.85) 0.70