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Fig. 9 | BMC Cancer

Fig. 9

From: Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis

Fig. 9

Diagrammatic representation of occurrence of colorectal cancer (a) and various modulatory mechanisms of combinatorial administration of probiotics and celecoxib (b) in CRC with respect to different biomarkers. (a) DMH-induced DNA methylation activates Wnt pathway which is accelerated by over expression of pro-inflammatory markers. Further, presence of harmful bacteria and production of toxic metabolites along with reduced pro-apoptotic markers leads to carcinogenesis. (b) Administration of probiotics and celecoxib modulate Wnt signaling pathway and ameliorate gut microbiome which could lead to reduced inflammation and enhanced apoptotic markers subsequently preventing carcinogenesis

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