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Table 6 Multivariate regression analysis with pCR as dependent variable

From: CEA clearance pattern as a predictor of tumor response to neoadjuvant treatment in rectal cancer: a post-hoc analysis of FOWARC trial

Variable pCR No pCR P Odds Ratio (95%CI)
Training cohort
 Tumor length    0.037 4.99 (1.10–22.63)
  4 cm 8 (73%) 22 (37%)   
   > 4 cm 3 (27%) 38 (63%)   
 CEA clearance pattern    0.013 8.30 (1.56–44.17)
  Exponential decrease (R20.9) 9 (82%) 22 (37%)   
  Non-exponential decrease (R2 < 0.9) 2 (18%) 38 (63%)   
Validation cohort
 Tumor length    0.484 0.59 (0.13–2.59)
  4 cm 3 (30%) 28 (43%)   
   > 4 cm 7 (70%) 37 (57%)   
 CEA clearance pattern    0.047 5.22 (1.02–26.60)
  Exponential decrease (R20.9) 8 (80%) 28 (43%)   
  Non-exponential decrease (R2 < 0.9) 2 (20%) 37 (57%)   
  1. Abbreviation: pCR pathologic complete response
  2. The p value in boldface means statistically significant, that is, less than 0.05