Fig. 1

Flowchart of the trial. (1) Baseline measurement will be conducted shortly after diagnosis and 1–3 days before beginning of patients’ medical treatment; (2) Participants allocated to the high-intensity interval endurance training perform 3 × 3 min high-intensive intervals, interspersed by 90 s active rest-intervals during the first 8 weeks of their chemotherapy (duration ≈ 20–25 min). During the second half of participants’ chemotherapy, the number of intervals will be increased to 5 (duration ≈ 30–35 min); (2) Participants allocated to the Placebo Control Group receive a supervised myofascial release training program, inducing hardly any muscular effort and cardiovascular stimulation. Duration of sessions in the Placebo Control Group correspond to the duration of sessions in the high-intensity interval endurance training