Table 4 Febrile neutropenia risk of CT regimen and additional risk factors per EORTC guidelines (analysis population)
Breast (n = 356) | Lung (n = 280) | GI: colorectal (n = 103) | GI: non-colorectal (n = 72) | GYN: ovarian (n = 72) | GYN: non-ovarian (n = 39) | Head & neck (n = 105) | Prostate (n = 66) | Other‡ (n = 81) | Total (n = 1174) | |
|---|---|---|---|---|---|---|---|---|---|---|
Patients with CT regimen in EORTC FN risk category, n (%) | ||||||||||
Low (< 10%) | 0 (0) | 15 (5.4) | 0 (0) | 0 (0) | 28 (38.9) | 0 (0) | 1 (1) | 0 (0) | 12 (14.8) | 56 (4.8) |
Intermediate (10–20%) | 253 (71.1) | 139 (49.6) | 43 (41.7) | 30 (41.7) | 2 (2.8) | 0 (0) | 5 (4.8) | 40 (60.6) | 1 (1.2) | 513 (43.7) |
High (≥ 20%) | 12 (3.4) | 30 (10.7) | 0 (0) | 1 (1.4) | 2 (2.8) | 0 (0) | 0 (0) | 0 (0) | 20 (24.7) | 65 (5.5) |
Unknown | 91 (25.6) | 96 (34.3) | 60 (58.3) | 41 (56.9) | 40 (55.6) | 39 (100) | 99 (94.3) | 26 (39.4) | 48 (59.3) | 540 (46.0) |
Patients with patient-related EORTC risk factor, n (%) | ||||||||||
Age > 65 years | 94 (26.4) | 120 (42.9) | 52 (50.5) | 34 (47.2) | 42 (58.3) | 24 (61.5) | 32 (30.5) | 53 (80.3) | 38 (46.9) | 489 (41.7) |
Female gender | 351 (98.6) | 87 (31.1) | 45 (43.7) | 26 (36.1) | 72 (100) | 39 (100) | 15 (14.3) | 0 (0) | 12 (14.8) | 647 (55.1) |
Advanced tumour: stage III or IV | 199 (55.9) | 265 (94.6) | 102 (99.0) | 66 (91.7) | 65 (90.3) | 34 (87.2) | 90 (85.7) | 65 (98.5) | 75 (92.6) | 961 (81.9) |
ECOG PS ≥ 2* | 34 (9.6) | 74 (26.7) | 8 (8.0) | 21 (29.6) | 16 (23.5) | 4 (11.1) | 14 (13.5) | 22 (34.4) | 20 (25.3) | 213 (18.5) |
Haemoglobin level < 12 g/dL* | 88 (27.7) | 120 (44.8) | 44 (44.0) | 39 (56.5) | 43 (64.2) | 25 (67.6) | 31 (36.0) | 38 (62.3) | 42 (53.2) | 470 (43.3) |
Prior episode of FN | 11 (3.1) | 10 (3.6) | 3 (2.9) | 5 (6.9) | 2 (2.8) | 0 (0) | 1 (1.0) | 2 (3.0) | 5 (6.2) | 39 (3.3) |
Concomitant pathologies with increased risk† | 11 (3.1) | 56 (20.0) | 5 (4.9) | 4 (5.6) | 4 (5.6) | 4 (10.3) | 9 (8.6) | 9 (13.6) | 19 (23.5) | 121 (10.3) |
No G-CSF use before inclusion | 318 (89.3) | 270 (96.4) | 90 (87.4) | 68 (94.4) | 64 (88.9) | 34 (87.2) | 99 (94.3) | 60 (90.9) | 72 (88.9) | 1075 (91.6) |