Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study

Table 2 Single nucleotide polymorphisms (SNPs) associated with estrogen and progestin combined therapy (EPT)-associated mammographic density change after multiple testing correction at gene level^a

SNP (gene)	Major/minor allele	Minor allele frequency	N (WW/WV/VV)	Beta (SE)	P (P_adj^b)
rs1983210 (INHA)	G/C	0.28	156/104/21	-1.80 (0.59)	0.003 (0.021)
rs35539615 (IGFBP1/3)	C/G	0.26	160/104/20	1.79 (0.59)	0.002 (0.043)
rs2278200 (INHA)^c	C/G	0.45	70/137/53	-1.55 (0.57)	0.008 (0.053)

^aBased on linear regression models adjusting for age and body mass index (BMI) at time of on-EPT mammogram, time interval and BMI change between the two mammograms, and mammographic density of on-EPT mammogram. Additive genetic model was used
^bP-values adjusted for multiple correlated tests (P_ACT) [37]
^crs1983210 and rs2278200 (INHA), r²=0.43

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