Two-dimensional speckle tracking echocardiography predicts early subclinical cardiotoxicity associated with anthracycline-trastuzumab chemotherapy in patients with breast cancer

Table 4 ROC Analysis of Echocardiographic Parameters at T1 for Predicting Cardiotoxicity (Decrease of ≥10% to EF ≤53%)

T1 Parameters	AUC	P Value	Odds Ratio (95% CI)	Cutoff Value	Sensitivity, %	Specificity, %
GLS, %	0.85	.003	1.47 (1.13-2.04)	−14.06	91	83
LSRs, l/s	0.54	.40	0.40 (0.04-3.46)	−0.86	93	30
LSRe, l/s	0.58	.25	2.55 (0.51-14.28)	0.94	82	47
CS, %	0.57	.04	1.15 (1.01-1.39)	−23.8	96	30
CSRs, l/s	0.58	.24	2.52 (0.55-13.06)	−1.46	67	52
CSRe, l/s	0.50	.98	1.01 (0.30-3.32)	1.0	96	16
RS, %	0.52	.07	0.96 (0.92-1.0)	33.27	56	75
RSRs, l/s	0.54	.65	0.85 (0.4-1.73)	1.86	41	73
RSRe, l/s	0.71	.005	0.33 (0.14-0.73)	−2.66	58	82
GLS + LSRe	0.90	<.001	1.94 (1.36-3.11) 93.40 (3.15-5807.32)	…	91	86
GLS + RSRe	0.88	<.001	1.57 (1.14-2.38) 0.26 (0.08-0.66)	…	91	78
RV GLS	0.53	0.93	0.99 (0.87-1.14)	−14.83	78	44
LV GLS + RV GLS	0.91	<.001	2.43 (1.43-5.34) 0.82 (0.62-1.03)	−14.83	100	73

Abbreviations: AUC area under the curve, CI confidence interval, CS circumferential strain, CSRe circumferential peak early diastolic strain rate, CSRs circumferential systolic strain rate, EF ejection fraction, GLS global longitudinal strain, LS longitudinal strain, LSRe longitudinal peak early diastolic strain rate, LSRs longitudinal peak systolic strain rate, RS radial strain, RSRe radial peak early diastolic strain rate, RSRs radial systolic strain rate, T1 time from start of chemotherapy to first echocardiogram

ISSN: 1471-2407